ArticleAmerican journal of human genetics2008
A genome-wide analysis of admixture in Uyghurs and a high-density admixture map for disease-gene discovery.
Article in American journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between gene polymorphism of TCF7L2 and type 2 diabetes in Chinese Han population: a meta-analysis.PloS one · 2013Pooled it
- Association Between KCNQ1 Genetic Variants and Type 2 Diabetes in the Uyghur Population.Genetic testing and molecular biomarkers · 2015Trial
- Admixture-driven structural variation diversity and its functional implications.National science review · 2026Article
- Divergent Eurasian ancestry and local adaptation shape the genetic landscapes of the Yugur and Uyghur.Briefings in bioinformatics · 2026Article
- Sex-Biased Admixture Followed by Isolation and Adaptive Evolution Shaped the Genomic and Blood Pressure Diversity of the LopNur People.Molecular biology and evolution · 2025Article
- Clinical features and genetic analysis of acrodermatitis enteropathica in an ethnic minority infant from Western China: a case report and literature review.Frontiers in medicine · 2025Article
- Analysis of sex-biased gene expression in a Eurasian admixed population.Briefings in bioinformatics · 2024Article
- Ancestral Origins and Admixture History of Kazakhs.Molecular biology and evolution · 2024Article
- Reconstructing complex admixture history using a hierarchical model.Briefings in bioinformatics · 2024Article
- Expression profiles of east-west highly differentiated genes in Uyghur genomes.National science review · 2023Article
- Comparative Genomic and Transcriptomic Analyses Reveal the Impacts of Genetic Admixture in Kazaks, Uyghurs, and Huis.Molecular biology and evolution · 2023Article
- Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences.Human genomics · 2023Article
- Article
- Genomic diversity and post-admixture adaptation in the Uyghurs.National science review · 2022Article
- Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human Diseases.International journal of molecular sciences · 2021Review
- Whole-Exome Sequencing Implicates theFrontiers in cell and developmental biology · 2021Article
- The Genetic Structure and East-West Population Admixture in Northwest China Inferred From Genome-Wide Array Genotyping.Frontiers in genetics · 2021Article
- The Heart of Silk Road "Xinjiang," Its Genetic Portray, and Forensic Parameters Inferred From Autosomal STRs.Frontiers in genetics · 2021Article
- Analysis ofAmerican journal of translational research · 2021Article
- Genetic and non-genetic factors associated with the phenotype of exceptional longevity & normal cognition.Scientific reports · 2020Article
15 more citing papers are in PubMed but not listed here.
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Abstract
Following up on our previous study, we conducted a genome-wide analysis of admixture for two Uyghur population samples (HGDP-UG and PanAsia-UG), collected from the northern and southern regions of Xinjiang in China, respectively. Both HGDP-UG and PanAsia-UG showed a substantial admixture of East-Asian (EAS) and European (EUR) ancestries, with an empirical estimation of ancestry contribution of 53:47 (EAS:EUR) and 48:52 for HGDP-UG and PanAsia-UG, respectively. The effective admixture time under a model with a single pulse of admixture was estimated as 110 generations and 129 generations, or admixture events occurred about 2200 and 2580 years ago for HGDP-UG and PanAsia-UG, respectively, assuming an average of 20 yr per generation. Despite Uyghurs' earlier history compared to other admixture populations, admixture mapping, holds promise for this population, because of its large size and its mixture of ancestry from different continents. We screened multiple databases and identified a genome-wide single-nucleotide polymorphism panel that can distinguish EAS and EUR ancestry of chromosomal segments in Uyghurs. The panel contains 8150 ancestry-informative markers (AIMs) showing large frequency differences between EAS and EUR populations (F(ST) > 0.25, mean F(ST) = 0.43) but small frequency differences (7999 AIMs validated) within both populations (F(ST) < 0.05, mean F(ST) < 0.01). We evaluated the effectiveness of this admixture map for localizing disease genes in two Uyghur populations. To our knowledge, our map constitutes the first practical resource for admixture mapping in Uyghurs, and it will enable studies of diseases showing differences in genetic risk between EUR and EAS populations.
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