ReviewBiochimica et biophysica acta2008
Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease.
Review in Biochimica et biophysica acta, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer's disease dementia.Alzheimer's research & therapy · 2025Article
- The GFAP proteoform puzzle: How to advance GFAP as a fluid biomarker in neurological diseases.Journal of neurochemistry · 2025Review
- Molecular Biomarkers for the Diagnosis, Prognosis, and Pharmacodynamics of Spinal Muscular Atrophy.Journal of clinical medicine · 2023Review
- Advanced Overview of Biomarkers and Techniques for Early Diagnosis of Alzheimer's Disease.Cellular and molecular neurobiology · 2023Review
- ALS plasma reduces the viability of NSC34 cells via altering mRNA expression of VEGF: A short report.Heliyon · 2023Article
- How Can Static and Oscillating Electric Fields Serve in Decomposing Alzheimer's and Other Senile Plaques?Journal of the American Chemical Society · 2023Article
- Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis.Acta neuropathologica communications · 2022Article
- The neuroinflammatory marker sTNFR2 relates to worse cognition and tau in women across the Alzheimer's disease spectrum.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- GABA synaptopathy promotes the elevation of caspases 3 and 9 as pro-apoptotic markers in Egyptian patients with autism spectrum disorder.Acta neurologica Belgica · 2021Article
- Biomarkers for the Clinical Diagnosis of Alzheimer's Disease: Metabolomics Analysis of Brain Tissue and Blood.Frontiers in pharmacology · 2021Review
- Comparison of Cerebrospinal Fluid Amyloidogenic Nanoplaques With Core Biomarkers of Alzheimer's Disease.Frontiers in aging neuroscience · 2020Article
- Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress.Oxidative medicine and cellular longevity · 2020Review
- Redox proteomics and amyloid β-peptide: insights into Alzheimer disease.Journal of neurochemistry · 2019Review
- Preconditioning in the Rhesus Macaque Induces a Proteomic Signature Following Cerebral Ischemia that Is Associated with Neuroprotection.Translational stroke research · 2019Article
- Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors.International journal of molecular sciences · 2019Article
- Amyloid Beta Peptide Is Released during Thrombosis in the Skin.International journal of molecular sciences · 2018Article
- Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2018Review
- Detection of a Peptide Biomarker by Engineered Yeast Receptors.ACS synthetic biology · 2018Article
- MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Alzheimer's disease (AD) affects millions of persons worldwide. Earlier detection and/or diagnosis of AD would permit earlier intervention, which conceivably could delay progression of this dementing disorder. In order to accomplish this goal, reliable and specific biomarkers are needed. Biomarkers are multidimensional and have the potential to aid in various facets of AD such as diagnostic prediction, assessment of disease stage, discrimination from normally cognitive controls as well as other forms of dementia, and therapeutic efficacy of AD drugs. To date, biomarker research has focused on plasma and cerebrospinal fluid (CSF), two bodily fluids believed to contain the richest source of biomarkers for AD. CSF is the fluid surrounding the central nervous system (CNS), and is the most indicative obtainable fluid of brain pathology. Blood plasma contains proteins that affect brain processes from the periphery, as well as proteins/peptides exported from the brain; this fluid would be ideal for biomarker discovery due to the ease and non-invasive process of sample collection. However, it seems reasonable that biomarker discovery will result in combinations of CSF, plasma, and other fluids such as urine, to serve the aforementioned purposes. This review focuses on proteins and peptides identified from CSF, plasma, and urine that may serve as biomarkers in AD.
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Registered trials
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