ArticleEmerging infectious diseases2008
Circulation of 3 lineages of a novel Saffold cardiovirus in humans.
Article in Emerging infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 121 citations in OpenAlex.
- Encephalomyocarditis virus (EMCV): An overlooked threat to primates.PLoS neglected tropical diseases · 2026Review
- Longitudinal analysis of the enteric virome in paediatric subjects from the Free State Province, South Africa, reveals early gut colonisation and temporal dynamics.Virus research · 2024Article
- Enterovirus genotype diversity with emergence of coxsackievirus A2 circulating in pediatric patients with acute gastroenteritis in Thailand, 2019-2022.Frontiers in microbiology · 2024Article
- Generation of a recombinant Saffold Virus expressing UnaG as a marker for the visualization of viral infection.Virology journal · 2023Article
- Detection of Six Different Human Enteric Viruses Contaminating Environmental Water in Chiang Mai, Thailand.Microbiology spectrum · 2023Article
- High Prevalence of Coinfecting Enteropathogens in Suspected Rotavirus Vaccine Breakthrough Cases.Journal of clinical microbiology · 2021Article
- Persistent Detection of Cosavirus and Saffold Cardiovirus in Riachuelo River, Argentina.Food and environmental virology · 2021Article
- First Occurrence of Saffold Virus in Sewage and River Water Samples in Karaj, Iran.Food and environmental virology · 2020Article
- Viruses in Vietnamese Patients Presenting with Community-Acquired Sepsis of Unknown Cause.Journal of clinical microbiology · 2019Article
- Frequent detection of Saffold cardiovirus in adenoids.PloS one · 2019Article
- Metagenomics detection and characterisation of viruses in faecal samples from Australian wild birds.Scientific reports · 2018Article
- A novel cardiovirus in wild rats.Virology journal · 2018Article
- An Opportunistic Pathogen Afforded Ample Opportunities: Middle East Respiratory Syndrome Coronavirus.Viruses · 2017Review
- Increased serum vascular endothelial growth factor is associated with acute viral encephalitis in Bangladeshi children.Scientific reports · 2017Article
- Highly diverse population of Picornaviridae and other members of the Picornavirales, in Cameroonian fruit bats.BMC genomics · 2017Article
- Saffold virus, an emerging human cardiovirus.Reviews in medical virology · 2017Review
- Immunohistochemical insights into Saffold virus infection of the brain of juvenile AG129 mice.Virology journal · 2016Article
- Intracerebral Inoculation of Mouse-Passaged Saffold Virus Type 3 Affects Cerebellar Development in Neonatal Mice.Journal of virology · 2016Article
- Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model.PLoS pathogens · 2016Article
- Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3.Journal of virology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple sclerosis-like disseminated encephalomyelitis. Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We conducted systematic molecular screening for Saffold-like viruses in 844 fecal samples from patients with gastroenteritis from Germany and Brazil, across all age groups. Six cardioviruses were identified in patients <6 years of age. Viral loads were 283,305-5,044,412,175 copies/g of stool. Co-infections occurred in 4 of 6 children. No evidence for outbreak-like epidemic patterns was found. Phylogenetic analysis identified 3 distinct genetic lineages. Viral protein 1 amino acids were 67.9%-77.7% identical and had a distance of at least 39.4% from known cardioviruses. Because closely related strains were found on 2 continents, global distribution in humans is suspected. Saffold-like viruses may be the first human cardiovirus species to be identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.