ArticleJournal of translational medicine2008
Non-compliance is the predominant cause of aspirin resistance in chronic coronary arterial disease patients.
Article in Journal of translational medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
- [Prevalence of acetylsalicylic acid (ASA) - low response in vascular surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2016Trial
- Effectiveness of antiplatelet therapy in atherosclerotic disease: comparing the ASA low-response prevalence in CVD, CAD and PAD.Journal of thrombosis and thrombolysis · 2014Trial
- Epigenome editing of human hematopoietic stem cells enables sustained and reversible thrombosis prevention.bioRxiv : the preprint server for biology · 2026Article
- Personalized Dual Antiplatelet Therapy in Acute Coronary Syndromes: Striking a Balance Between Bleeding and Thrombosis.Current cardiology reports · 2023Review
- Contemporary Antiplatelet and Anticoagulant Therapies for Secondary Stroke Prevention: A Narrative Review of Current Literature and Guidelines.Current neurology and neuroscience reports · 2023Review
- Antiplatelet Use in Ischemic Stroke.The Annals of pharmacotherapy · 2022Review
- Aspirin Use and Transcatheter Pulmonary Valve Replacement, the Need for Consistency.Pediatric cardiology · 2021Article
- [Evaluation of treatment adaptation for low response to ASA in vascular surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Article
- Prevalence rate of laboratory defined aspirin resistance in cardiovascular disease patients: A systematic review and meta-analysis.Caspian journal of internal medicine · 2020Review
- Perioperative changes of response to antiplatelet medication in vascular surgery patients.PloS one · 2020Observational
- The lack of aspirin resistance in patients with coronary artery disease.Journal of translational medicine · 2016Article
- Anti-platelet Therapy Resistance - Concept, Mechanisms and Platelet Function Tests in Intensive Care Facilities.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2016Article
- Impairment of aspirin antiplatelet effects by non-opioid analgesic medication.World journal of cardiology · 2015Review
- Searching for factors associated with resistance to acetylsalicylic acid used for secondary prevention of stroke.Archives of medical science : AMS · 2015Article
- Confirmation of reported aspirin use in community studies: utility of serum thromboxane B2 measurement.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2014Article
- Resistance to acetylsalicylic acid in patients with type 2 diabetes mellitus is associated with lipid disorders and history of current smoking.Journal of endocrinological investigation · 2014Article
- Genetic determinants of on-aspirin platelet reactivity: focus on the influence of PEAR1.PloS one · 2014Observational
- Microfluidic assay of platelet deposition on collagen by perfusion of whole blood from healthy individuals taking aspirin.Clinical chemistry · 2013Article
- Monitoring aspirin and clopidogrel response: testing controversies and recommendations.Molecular diagnosis & therapy · 2013Review
- Plasma proteome changes in cardiovascular disease patients: novel isoforms of apolipoprotein A1.Journal of translational medicine · 2011Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur previous publication showed that 9% of patients with a history of myocardial infarction MI. could be labeled as aspirin resistant; all of these patients were aspirin resistant because of non-compliance. This report compares the relative frequency of aspirin resistance between known compliant and non-compliance subjects to demonstrate that non-compliance is the predominant cause of aspirin resistance.
methodsThe difference in the slopes of the platelet prostaglandin agonist (PPA) light aggregation curves off aspirin and 2 hours after observed aspirin ingestion was defined as net aspirin inhibition.
resultsAfter supposedly refraining from aspirin for 7 days, 46 subjects were judged non-compliant with the protocol. Of the remaining 184 compliant subjects 39 were normals and 145 had a past history of MI. In known compliant subjects there was no difference in net aspirin inhibition between normal and MI subjects. Net aspirin inhibition in known compliant patients was statistically normally distributed. Only 3% of compliant subjects (2 normals and 5 MI) had a net aspirin inhibitory response of less than one standard deviation which could qualify as a conservative designation of aspirin resistance. A maximum of 35% of the 191 post MI subjects could be classified as aspirin resistant and/or non-compliant: 9% aspirin resistant because of non-compliance, 23% non-compliant with the protocol and possibly 3% because of a decreased net aspirin inhibitory response in known compliant patients.
conclusionOur data supports the thesis that the predominant cause of aspirin resistance is noncompliance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.