ArticleTissue engineering. Part A2009
Engineering endochondral bone: in vivo studies.
Article in Tissue engineering. Part A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 103 citations in OpenAlex.
- A Bioglass-Poly(lactic-co-glycolic Acid) Scaffold@Fibrin Hydrogel Construct to Support Endochondral Bone Formation.Advanced healthcare materials · 2023Article
- Close-to-native bone repair via tissue-engineered endochondral ossification approaches.iScience · 2022Review
- Turning Nature's own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering.Advanced drug delivery reviews · 2021Review
- Orthotopic Bone Formation by Streamlined Engineering and Devitalization of Human Hypertrophic Cartilage.International journal of molecular sciences · 2020Article
- Biomaterial-based endochondral bone regeneration: a shift from traditional tissue engineering paradigms to developmentally inspired strategies.Materials today. Bio · 2019Review
- Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects.Frontiers in bioengineering and biotechnology · 2018Review
- Macrophage interactions with polylactic acid and chitosan scaffolds lead to improved recruitment of human mesenchymal stem/stromal cells: a comprehensive study with different immune cells.Journal of the Royal Society, Interface · 2016Article
- Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes.Tissue engineering. Part A · 2016Article
- Review
- Effects of in vitro endochondral priming and pre-vascularisation of human MSC cellular aggregates in vivo.Stem cell research & therapy · 2015Article
- Endochondral ossification for enhancing bone regeneration: converging native extracellular matrix biomaterials and developmental engineering in vivo.Tissue engineering. Part B, Reviews · 2015Review
- Chitosan and Its Potential Use as a Scaffold for Tissue Engineering in Regenerative Medicine.BioMed research international · 2015Review
- Formation of cartilage and synovial tissue by human gingival stem cells.Stem cells and development · 2014Article
- Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Developmental-like bone regeneration by human embryonic stem cell-derived mesenchymal cells.Tissue engineering. Part A · 2014Article
- Progress and challenges in biomaterials used for bone tissue engineering: bioactive glasses and elastomeric composites.Progress in biomaterials · 2012Article
- Enhanced mesenchymal stromal cell recruitment via natural killer cells by incorporation of inflammatory signals in biomaterials.Journal of the Royal Society, Interface · 2012Article
- Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.PloS one · 2012Article
- Stem cell-based bone repair.American journal of stem cells · 2012Article
- In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells.BMC musculoskeletal disorders · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The use of biomaterials to replace lost bone has been a common practice for decades. More recently, the demands for bone repair and regeneration have pushed research into the use of cultured cells and growth factors in association with these materials. Here we report a novel approach to engineer new bone using a transient cartilage scaffold to induce endochondral ossification. Chondrocyte/chitosan scaffolds (both a transient cartilage scaffold-experimental-and a permanent cartilage scaffold-control) were prepared and implanted subcutaneously in nude mice. Bone formation was evaluated over a period of 5 months. Mineralization was assessed by Faxitron, micro computed tomography, backscatter electrons, and Fourier transform infrared spectroscopy analyses. Histological analysis provided further information on tissue changes in and around the implanted scaffolds. The deposition of ectopic bone was detected in the surface of the experimental implants as early as 1 month after implantation. After 3 months, bone trabeculae and bone marrow cavities were formed inside the scaffolds. The bone deposited was similar to the bone of the mice vertebra. Interestingly, no bone formation was observed in control implants. In conclusion, an engineered transient cartilage template carries all the signals necessary to induce endochondral bone formation in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.