ReviewAnnual review of physiology2009
Recent advances in understanding integrative control of potassium homeostasis.
Review in Annual review of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed, 149 citations in OpenAlex.
- Quantitative analysis of skeletal muscle contributions to ECF KAmerican journal of physiology. Cell physiology · 2026Review
- p38 MAPK orchestrates cross-tissue potassium homeostasis for survival.Nature communications · 2026Article
- Mechanisms of the viscosity decrease and increase of aqueous CsCl.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Following the Hyperkalemia Trail: A Case Report of ECG Changes and Treatment Responses.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025Article
- Can Dietary Supplements Support Muscle Function and Physical Activity? A Narrative Review.Nutrients · 2025Review
- Effect of Potassium-Magnesium Sulfate on Intestinal Dissociation and Absorption Rate, Immune Function, and Expression of NLRP3 Inflammasome, Aquaporins and Ion Channels in Weaned Piglets.Animals : an open access journal from MDPI · 2025Article
- Bolus doses of insulin versus a continuous insulin infusion for treating hyperkalaemia in adults: A case series.SAGE open medical case reports · 2025Article
- Sociodemographic and clinical factors influencing serum potassium concentration: A retrospective cohort study.Computational and structural biotechnology journal · 2024Article
- Role of calcineurin in regulating renal potassium (KActa physiologica (Oxford, England) · 2024Review
- The Prevalence and Risk Factors of Hyperkalemia in the Outpatient Setting.International journal of nephrology · 2024Article
- Analysis of urinary potassium isotopes and association with pancreatic health: healthy, diabetic and cancerous states.Frontiers in endocrinology · 2024Article
- TRPV4 expression in the renal tubule is necessary for maintaining whole body KAmerican journal of physiology. Renal physiology · 2023Article
- Real-World Modifications of Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Hyperkalemia Initiating Sodium Zirconium Cyclosilicate Therapy: The OPTIMIZE I Study.Advances in therapy · 2023Article
- Aldosterone: Renal Action and Physiological Effects.Comprehensive Physiology · 2023Article
- Gene mutations in comorbidity of epilepsy and arrhythmia.Journal of neurology · 2023Review
- Estimating in vivo potassium distribution and fluxes with stable potassium isotopes.American journal of physiology. Cell physiology · 2022Article
- Review of the Pathophysiologic and Clinical Aspects of Hypokalemia in Children and Young Adults: an Update.Current treatment options in pediatrics · 2022Review
- Stable potassium isotopes (Frontiers in physiology · 2022Article
- Molecular and physical technologies for monitoring fluid and electrolyte imbalance: A focus on cancer population.Clinical and translational medicine · 2021Review
- Inwardly Rectifying Potassium Channel Kir2.1 and its "Kir-ious" Regulation by Protein Trafficking and Roles in Development and Disease.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The potassium homeostatic system is very tightly regulated. Recent studies have shed light on the sensing and molecular mechanisms responsible for this tight control. In addition to classic feedback regulation mediated by a rise in extracellular fluid (ECF) [K(+)], there is evidence for a feedforward mechanism: Dietary K(+) intake is sensed in the gut, and an unidentified gut factor is activated to stimulate renal K(+) excretion. This pathway may explain renal and extrarenal responses to altered K(+) intake that occur independently of changes in ECF [K(+)]. Mechanisms for conserving ECF K(+) during fasting or K(+) deprivation have been described: Kidney NADPH oxidase activation initiates a cascade that provokes the retraction of K(+) channels from the cell membrane, and muscle becomes resistant to insulin stimulation of cellular K(+) uptake. How these mechanisms are triggered by K(+) deprivation remains unclear. Cellular AMP kinase-dependent protein kinase activity provokes the acute transfer of K(+) from the ECF to the ICF, which may be important in exercise or ischemia. These recent advances may shed light on the beneficial effects of a high-K(+) diet for the cardiovascular system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.