ArticleJournal of the American Chemical Society2008
A stereoselective synthesis of (+)-gonyautoxin 3.
Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 105 citations in OpenAlex.
- A designer saxitoxin-engineered sodium channel pair as a general tool for subtype-selective inhibition.Cell chemical biology · 2026Article
- Saxiphilin is a broad-spectrum toxin sponge for C13-modified saxitoxins.bioRxiv : the preprint server for biology · 2026Article
- Article
- Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.Nature communications · 2025Article
- Synthesis of Saxitoxin Biosynthetic Intermediates: Reveal the Mechanism for Formation of its Tricyclic Skeleton in Biosynthesis.Chemistry, an Asian journal · 2024Article
- The Chemistry of Phytoplankton.Chemical reviews · 2024Review
- Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin.Nature communications · 2021Article
- Scalable Synthesis of Esp and Rhodium(II) Carboxylates from Acetylacetone and RhClOrganic process research & development · 2020Article
- Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor.Marine drugs · 2019Review
- Divergent Synthesis of Natural Derivatives of (+)-Saxitoxin Including 11-Saxitoxinethanoic Acid.Angewandte Chemie (International ed. in English) · 2019Article
- Synthesis of Benzannulated Medium-ring Lactams via a Tandem Oxidative Dearomatization-Ring Expansion Reaction.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Synthesis of azasilacyclopentenes and silanolsChemical science · 2017Article
- Synthesis of Cyclic Guanidines Bearing N-Arylsulfonyl and N-Cyano Protecting Groups via Pd-Catalyzed Alkene Carboamination Reactions.Organic letters · 2017Article
- Stereoselective Synthesis of Cyclic Guanidines by Directed Diamination of Unactivated Alkenes.Organic letters · 2016Article
- Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Synthesis of Cyclic Guanidines via Silver-Catalyzed Intramolecular Alkene Hydroamination Reactions of N-Allylguanidines.Organic letters · 2016Article
- Syntheses of Cyclic Guanidine-Containing Natural Products.Tetrahedron · 2015Article
- Synthesis of bicyclic guanidines via cascade hydroamination/Michael additions of mono-N-acryloylpropargylguanidines.Organic letters · 2014Article
- Synthetic studies towards Zetekitoxin AB: preparation of 4,5-epi-11-hydroxy-saxitoxinol.Tetrahedron · 2014Article
- Iron(II)-catalyzed intermolecular amino-oxygenation of olefins through the N-O bond cleavage of functionalized hydroxylamines.Journal of the American Chemical Society · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
An asymmetric synthesis of the paralytic shellfish poison (PSP), (+)-gonyautoxin 3, is described. A unique, Rh-catalyzed amination reaction provides rapid access to the heteratom-rich, tricyclic core of the toxin, which is common to more than 30 related natural products. The completed route should facilitate the preparation of other naturally occurring PSPs and designed analogues thereof.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.