ArticleGenetica2009
The genetic architecture of complex behaviors: lessons from Drosophila.
Article in Genetica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Courtship song differs between African and European populations of Drosophila melanogaster and involves a strong effect locus.G3 (Bethesda, Md.) · 2025Article
- Evolution of threat response-related polymorphisms at theBiology letters · 2024Article
- The complex genetic architecture of male mate choice evolution between Drosophila species.Heredity · 2020Article
- Evolution of Epistatic Networks and the Genetic Basis of Innate Behaviors.Trends in genetics : TIG · 2020Review
- Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits.Genetics · 2017Article
- Sexually antagonistic selection on genetic variation underlying both male and female same-sex sexual behavior.BMC evolutionary biology · 2016Article
- Genetic architecture underlying host choice differentiation in the sympatric host races of Lochmaea capreae leaf beetles.Genetica · 2016Article
- Integrating molecular mechanisms into quantitative genetics to understand consistent individual differences in behavior.Current opinion in behavioral sciences · 2015Article
- Genetics, lifestyle and longevity: Lessons from centenarians.Applied & translational genomics · 2015Review
- Looking under the lamp post: neither fruitless nor doublesex has evolved to generate divergent male courtship in Drosophila.Cell reports · 2014Article
- The draft genome of a socially polymorphic halictid bee, Lasioglossum albipes.Genome biology · 2013Article
- What can whole genome expression data tell us about the ecology and evolution of personality?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- The population genetics of mutations: good, bad and indifferent.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
- The role of genetics in the etiology of schizophrenia.The Psychiatric clinics of North America · 2010Review
- Understanding and using quantitative genetic variation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
- Genetic architecture underlying convergent evolution of egg-laying behavior in a seed-feeding beetle.Genetica · 2009Article
- Approaching the genomics of risk-taking behavior.Advances in genetics · 2009Review
- Drosophotoxicology: the growing potential for Drosophila in neurotoxicology.Neurotoxicology and teratologyReview
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Complex behaviors are affected by multiple interacting loci with individually small and environmentally sensitive effects. Understanding the genetic architecture of behavioral traits begins with identifying the genes regulating these traits, mapping the subset of genetically varying quantitative trait loci (QTLs) in natural populations, and pinpointing the molecular polymorphisms defining QTL alleles. Drosophila brings an impressive toolkit to the challenge of genetically dissecting complex traits: P transposable element mutagenesis to identify genes regulating these traits; artificial selection from natural populations to create extreme trait phenotypes; high resolution mapping to identify positional candidate genes corresponding to QTLs; linkage disequilibrium mapping to identify molecular polymorphism(s) that functionally define QTL alleles; and whole genome transcriptional profiling to postulate networks of interacting genes affecting complex traits. Studies in Drosophila have revealed large numbers of pleiotropic genes that interact epistatically to regulate behavioral traits, and that can have sex- and environment-specific effects. These observations offer valuable lessons for understanding the genetic basis of variation for complex behaviors in other organisms, including humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.