ArticleNeurochemical research2009
Glucocorticoid receptor changes associate with age in the paraventricular nucleus of type II diabetic rat model.
Article in Neurochemical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Effects of Saffron Extract (AffronNutrients · 2023Article
- Effects of exercise on brain functions in diabetic animal models.World journal of diabetes · 2015Review
- Treadmill exercise prevents diabetes-induced increases in lipid peroxidation and decreases in Cu,Zn-superoxide dismutase levels in the hippocampus of Zucker diabetic fatty rats.Journal of veterinary science · 2015Article
- Sequential alterations of glucocorticoid receptors in the hippocampus of STZ-treated type 1 diabetic rats.Journal of veterinary science · 2014Article
- Treadmill exercise exerts ameliorating effect on isolation-induced depression via neuronal activation.Journal of exercise rehabilitation · 2013Article
- Time-dependent changes of calbindin D-28K and parvalbumin immunoreactivity in the hippocampus of rats with streptozotocin-induced type 1 diabetes.Journal of veterinary science · 2013Article
- The chronological characteristics of SOD1 activity and inflammatory response in the hippocampi of STZ-induced type 1 diabetic rats.Neurochemical research · 2011Article
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Abstract
Diabetes is a metabolic disorder that is associated with the dysregulation of a number of systems within the body. In the present study, we investigated glucocorticoid receptor (GR) immunoreactivity and its protein levels in the paraventricular nuclei of 4-, 12-, 20- and 30-week-old Zucker diabetic fatty (fa/fa, ZDF) and in Zucker lean control (fa/+ or +/+, ZLC) rats, because the progressive induction of diabetes is detectable in this model after 7 weeks of age and chronic diabetic conditions are maintained after 12 weeks of age. GR immunoreactivity was detected in parvocellular paraventricular nuclei and this and GR protein levels were exponentially increased according to the ages. In particular, GR immunoreactivities and protein levels were markedly more increased in 30-week-old ZDF rats than in age-matched ZLC group and in younger ZDF group. The present study suggests that GR immunoreactivity and its protein level is associated with a degenerative phenotype in the hypothalamus of from 12-weeks old in the ZDF rat type II diabetes model.
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