Trial reportJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2009
Post-operative atrial fibrillation management by selective epicardial vagal fat pad stimulation.
Trial report in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01095952 (Reduction of Ventricular Rate During Atrial Fibrillation by AV Node Stimulation" AVNS Download Study), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reduction of Ventricular Rate During Atrial Fibrillation by AV Node Stimulation" AVNS Download Study
Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- Nonpharmacologic rate control of postoperative atrial fibrillation in the canine sterile pericarditis model.Journal of cardiovascular electrophysiology · 2024Article
- Effects of Vagal Nerve Stimulation on Ganglionated Plexi Nerve Activity and Ventricular Rate in Ambulatory Dogs With Persistent Atrial Fibrillation.JACC. Clinical electrophysiology · 2018Article
- Simultaneous recordings of intrinsic cardiac nerve activity and skin sympathetic nerve activity from human patients during the postoperative period.Heart rhythm · 2017Article
- Selective autonomic stimulation of the AV node fat pad to control rapid post-operative atrial arrhythmias.PloS one · 2017Article
- Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy.Circulation research · 2014Review
- Electrophysiological changes preceding the onset of atrial fibrillation after coronary bypass grafting surgery.PloS one · 2014Article
- Neural control of ventricular rate in ambulatory dogs with pacing-induced sustained atrial fibrillation.Circulation. Arrhythmia and electrophysiology · 2012Article
- Stimulation of the intra-cardiac vagal nerves innervating the AV-node to control ventricular rate during AF: specificity, parameter optimization and chronic use up to 3 months.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2012Article
- Arrhythmias and vagus nerve stimulation.Heart failure reviews · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePost-operative atrial fibrillation (POAF) is a common complication after cardiac surgery and often leads to poorly tolerated fast ventricular rates. Negative dromotropic drugs are not always effective and may not be well tolerated in heart failure patients. Aim of this study is to verify if high-frequency stimulation of the right inferior fat pad (RIFPS) allows an effective decrease in ventricular rate (VR) during POAF.
methodsWe enrolled 32 consecutive patients submitted to bypass; during surgery, a temporary heart wire was implanted in a site where RIFPS evoked a functional AV block. During POAF, RIFPS was delivered from the heart wire to decrease VR.
resultsIntra-operative RIFPS evoked complete AV block in 29 patients (91%). Fourteen patients (44%) developed POAF (mean VR 127 +/- 12 bpm). In these patients, RIFPS achieved a 25% reduction of VR and complete AV block with 6.0 +/- 1.9 and 7.5 +/- 1.8 V (duration 0.2 ms, frequency 50 Hz), respectively.
conclusionEpicardial RIFPS represents an effective and feasible technique to decrease VR during POAF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.