ArticleJournal of plant research2008
NtbZIP60, an endoplasmic reticulum-localized transcription factor, plays a role in the defense response against bacterial pathogens in Nicotiana tabacum.
Article in Journal of plant research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 69 citations in OpenAlex.
- Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant-Pathogen Interface.Plant biotechnology journal · 2026Review
- Article
- The plant endoplasmic reticulum UPRome: A repository and pathway browser for genes involved in signaling networks linked to the endoplasmic reticulum.Plant direct · 2022Article
- Endoplasmic Reticulum Stress and Unfolded Protein Response Signaling in Plants.International journal of molecular sciences · 2022Review
- Susceptibility factor RTP1 negatively regulates Phytophthora parasitica resistance via modulating UPR regulators bZIP60 and bZIP28.Plant physiology · 2021Article
- Genome-Wide Identification and Expression Analysis of the StrawberryPlants (Basel, Switzerland) · 2020Article
- IRE1-bZIP60 Pathway Is Required forFrontiers in plant science · 2019Article
- TabZIP74 Acts as a Positive Regulator in Wheat Stripe Rust Resistance and Involves Root Development by mRNA Splicing.Frontiers in plant science · 2019Article
- The Unfolded Protein Response Supports Plant Development and Defense as well as Responses to Abiotic Stress.Frontiers in plant science · 2017Review
- The polyamine spermine induces the unfolded protein response via the MAPK cascade in Arabidopsis.Frontiers in plant science · 2015Article
- Emerging functions of the unfolded protein response in immunity.Nature immunology · 2014Review
- Endoplasmic reticulum (ER) stress response and its physiological roles in plants.International journal of molecular sciences · 2013Review
- TGBp3 triggers the unfolded protein response and SKP1-dependent programmed cell death.Molecular plant pathology · 2013Article
- The endoplasmic reticulum: a sensor of cellular stress that modulates immune responses.Microbes and infection · 2012Review
- IRE1/bZIP60-mediated unfolded protein response plays distinct roles in plant immunity and abiotic stress responses.PloS one · 2012Article
- The endoplasmic reticulum in plant immunity and cell death.Frontiers in plant science · 2012Article
- ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.The Journal of experimental medicine · 2011Article
- The unfolded protein response is triggered by a plant viral movement protein.Plant physiology · 2011Article
- The Bphi008a gene interacts with the ethylene pathway and transcriptionally regulates MAPK genes in the response of rice to brown planthopper feeding.Plant physiology · 2011Article
- Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum.Current opinion in immunology · 2011Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A spermine-based signal transduction pathway plays a defensive role against incompatible pathogens. We identified a novel spermine-responsive cDNA from Nicotiana tabacum that encodes a basic region/leucine zipper protein with a putative transmembrane domain. Identity to Arabidopsis thaliana AtbZIP60 was sufficiently high to name the novel cDNA NtbZIP60. Expression analysis revealed that NtbZIP60 is a component of the spermine-signal pathway, and is also involved in the unfolded protein response (UPR), as demonstrated for AtbZIP60. The gene product, NtbZIP60, localizes to the endoplasmic reticulum (ER) in plant cells; once the putative transmembrane domain is eliminated from the intact protein, it targets the nucleus. The putative processed form of NtbZIP60 transactivates target genes through binding to plant-specific UPR cis-elements. Expression of NbbZIP60, an NtbZIP60 ortholog in Nicotiana benthamiana, was significantly up-regulated at 6 h and later time points upon infection with the non-host pathogen Pseudomonas cichorii, while it was unaffected by infection with the compatible pathogen Pseudomonas syringae pv. tabaci. Furthermore, NbbZIP60-silenced N. benthamiana plants allowed higher multiplication of P. cichorii compared to the control plants. Taken together, the results suggest that this ER-localized transcription factor is involved in the spermine-signal transduction pathway and plays an important role in plant innate immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.