ArticleDevelopment genes and evolution2008
Conserved cluster organization of insect Runx genes.
Article in Development genes and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- The transcription factor RUNT-like regulates pupal cuticle development via promoting a pupal cuticle protein transcription.PLoS genetics · 2024Article
- RUNX3 mediates keloid fibroblast proliferation through deacetylation of EZH2 by SIRT1.BMC molecular and cell biology · 2022Article
- RUNX1-dependent mechanisms in biological control and dysregulation in cancer.Journal of cellular physiology · 2019Review
- Evolution of the pair rule gene network: Insights from a centipede.Developmental biology · 2013Article
- How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation.Development (Cambridge, England) · 2011Article
- Distinct contributions of conserved modules to Runt transcription factor activity.Molecular biology of the cell · 2010Article
- Is Runx a linchpin for developmental signaling in metazoans?Journal of cellular biochemistry · 2009Article
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2 authors at 1 institution in 1 country.
Funding
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Abstract
Runx gene family transcription factors play important regulatory roles in metazoan development. The Drosophila genome contains four Runx genes, two of which are well studied (runt and lozenge) and two of which have not been explored in depth yet (CG42267 and CG34145). In the absence of paralog-specific orthologs in vertebrates, we investigated the evolutionary conservation of the Drosophila Runx genes in the genomes of mosquito, red flour beetle, honeybee, and distantly related Bilateria. All four Drosophila Runx genes are conserved in other endopterygote insects. Strikingly, their genetic linkage and genomic arrangement is also highly conserved despite past recombination events in the same genomic region. The preservation of Runx gene cluster organization for at least 300 million years resembles that of insect Hox and selected Wnt genes. We propose a model for the conserved cluster organization of developmental gene family paralogs based on differential coduplication of regulatory elements that act over long distances.
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