ArticlePsychopharmacology2008
Arcaine and MK-801 make recall state-dependent in rats.
Article in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Cooperative binding of bivalent ligands yields new insights into the guanidine-II riboswitch.NAR genomics and bioinformatics · 2024Article
- State-dependent memory retrieval: insights from neural dynamics and behavioral perspectives.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- MK-801 and cognitive functions: Investigating the behavioral effects of a non-competitive NMDA receptor antagonist.Psychopharmacology · 2023Review
- State-dependent memory and its modulation by different brain areas and neurotransmitters.EXCLI journal · 2020Review
- The NMDA receptor antagonist MK-801 fails to impair long-term recognition memory in mice when the state-dependency of memory is controlled.Neurobiology of learning and memory · 2019Article
- Structure-guided design of a high-affinity ligand for a riboswitch.RNA (New York, N.Y.) · 2019Article
- Mammillary body regulates state-dependent fear by alternating cortical oscillations.Scientific reports · 2018Article
- Cross state-dependency of learning between tramadol and MK-801 in the mouse dorsal hippocampus: involvement of nitric oxide (NO) signaling pathway.Psychopharmacology · 2018Article
- A Nonrewarding NMDA Receptor Antagonist Impairs the Acquisition, Consolidation, and Expression of Morphine Conditioned Place Preference in Mice.Molecular neurobiology · 2017Article
- The Influence of the CB1 Receptor Ligands on the Schizophrenia-Like Effects in Mice Induced by MK-801.Neurotoxicity research · 2016Article
- Spermine reverses lipopolysaccharide-induced memory deficit in mice.Journal of neuroinflammation · 2015Article
- Reconsolidation of a well-learned instrumental memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Effects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance task.Psychopharmacology · 2013Article
- Over-expectation generated in a complex appetitive goal-tracking task is capable of inducing memory reconsolidation.Psychopharmacology · 2013Article
- Effect of naloxone and morphine on arcaine-induced state-dependent memory in rats.Psychopharmacology · 2011Article
- Clinical physiology and mechanism of dizocilpine (MK-801): electron transfer, radicals, redox metabolites and bioactivity.Oxidative medicine and cellular longevityReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe polyamines putrescine, spermidine, and spermine are a group of aliphatic amines that may act as physiological modulators of the N-methyl-D-aspartate (NMDA) receptor, a glutamate receptor implicated in memory formation and consolidation. Arcaine is a competitive antagonist of the polyamine binding site at the NMDA receptor, the post-training administration of which impairs memory of various tasks.
objectivesIn this study, we investigated whether the administration of arcaine and MK-801 alters the memory of the step-down inhibitory avoidance task, and whether the effects of these NMDA antagonists involve state-dependency mechanisms, in adult male Wistar rats.
resultsThe administration of arcaine (30 mg/kg, i.p.) or MK-801 (0.03 mg/kg, i.p.) immediately after training impaired inhibitory avoidance performance at testing. Arcaine- and MK-801-induced performance impairment was reversed by the administration of arcaine (30 mg/kg, i.p.) and MK-801 (0.03 mg/kg, i.p.), respectively, 30 min before testing. Response transfer also occurred if arcaine substituted MK-801 at testing, and vice-versa.
conclusionThese results suggest that arcaine and MK-801 induce state-dependent recall and that, probably due to their ability to decrease NMDA receptor function, one drug can substitute for the other at testing, demonstrating a cross-state dependency between arcaine and MK-801.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.