ArticlePlant molecular biology2008
The Arabidopsis homeodomain-leucine zipper II gene family: diversity and redundancy.
Article in Plant molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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61 citing papers in PubMed, 143 citations in OpenAlex.
- SIZ1-mediated SUMOylation of HAT1 enhances plant thermotolerance in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Genome-wide identification of theFrontiers in plant science · 2026Article
- The HD-ZIP II Transcription Factors HAT3 and ATHB4 Fine-Tune Auxin and Cytokinin Pathways During Flower Development.Plants (Basel, Switzerland) · 2025Article
- Domain characteristics, classification and expression profiles in response to various abiotic stresses of four HD-Zip subfamilies in tea plant.BMC plant biology · 2025Article
- Functional study of ZmHDZ4 in maize (Zea mays) seedlings under drought stress.BMC plant biology · 2024Article
- Genome-wide analysis of HD-Zip genes in Sophora alopecuroides and their role in salt stress response.The plant genome · 2024Article
- 'Organ'ising Floral Organ Development.Plants (Basel, Switzerland) · 2024Review
- Genome-wide characterisation of HD-Zip transcription factors and functional analysis of PbHB24 during stone cell formation in Chinese white pear (Pyrus bretschneideri).BMC plant biology · 2024Article
- The Ins and Outs of Homeodomain-Leucine Zipper/Hormone Networks in the Regulation of Plant Development.International journal of molecular sciences · 2024Review
- Comprehensive bioinformation analysis of homeodomain-leucine zipper gene family and expression pattern of HD-Zip I under abiotic stress in Salix suchowensis.BMC genomics · 2024Article
- Genome-wide characterization and expression profiling of the HD-ZIP gene family in Acoraceae under salinity and cold stress.Frontiers in plant science · 2024Article
- Genome-wide identification of HD-ZIP gene family and screening of genes related to prickle development in Zanthoxylum armatum.The plant genome · 2023Article
- Arabidopsis homeobox-leucine zipper transcription factor BRASSINOSTEROID-RELATED HOMEOBOX 3 regulates leaf greenness by suppressing BR signaling.Plant biotechnology (Tokyo, Japan) · 2022Article
- Article
- Genome-Wide Identification, Classification, and Expression Analysis of the HD-Zip Transcription Factor Family in Apple (International journal of molecular sciences · 2022Article
- Genome-wide identification of HD-ZIP transcription factors in maize and their regulatory roles in promoting drought tolerance.Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- microRNA 166: an evolutionarily conserved stress biomarker in land plants targeting HD-ZIP family.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Review
- Genetic transformation and growth index determination of the Larix olgensis LoHDZ2 transcription factor gene in tobacco.Scientific reports · 2021Article
- Review
- A moso bamboo transcription factor, Phehdz1, positively regulates the drought stress response of transgenic rice.Plant cell reports · 2021Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arabidopsis genome contains 10 genes belonging to the HD-Zip II family including ATHB2 and HAT2. Previous work has shown that ATHB2 is rapidly and strongly induced by light quality changes that provoke the shade avoidance response whereas HAT2 expression responds to auxin. Here, we present a genome-wide analysis of the HD-Zip II family. Phylogeny reconstruction revealed that almost all of the HD-Zip II genes can be subdivided into 4 clades (alpha-delta), each clade comprising 2-3 paralogs. Gene expression studies demonstrated that all the gamma and delta genes are regulated by light quality changes. Kinetics of induction, low R/FR/high R/FR reversibility and auxin response analyses strongly suggested that HAT1, HAT3 and ATHB4, as ATHB2, are under the control of the phytochrome system whereas HAT2 is up-regulated by low R/FR as a consequence of the induction of the auxin signaling pathway provoked by FR-rich light. Root and shoot digital in situ revealed that gamma and delta genes are also tightly regulated during plant development with both distinct and overlapping patterns. Phenotypes of gain of function and dominant negative lines demonstrated that one or more of the HD-Zip II gamma genes negatively regulate cell proliferation during leaf development in a high R/FR light environment. Finally, target gene analysis using a chimeric transcription factor (HD-Zip2-V-G), known to activate ATHB2 target genes in a glucocorticoid-dependent manner, revealed that all the 10 HD-Zip II genes can be recognized by the HD-Zip 2 domain in vivo, implying an intricate negative feedback network.
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