ArticleNature medicine2008
Attenuated Plasmodium yoelii lacking purine nucleoside phosphorylase confer protective immunity.
Article in Nature medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Pooled it
- Experimental vaccination by single dose sporozoite injection of blood-stage attenuated malaria parasites.EMBO molecular medicine · 2024Article
- Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848.The Journal of biological chemistry · 2024Article
- Five decades of clinical assessment of whole-sporozoite malaria vaccines.Frontiers in immunology · 2022Review
- The pink salmon genome: Uncovering the genomic consequences of a two-year life cycle.PloS one · 2021Article
- Whole-Killed Blood-Stage Vaccine: Is It Worthwhile to Further Develop It to Control Malaria?Frontiers in microbiology · 2021Review
- A genetically hmgb2 attenuated blood stage P. berghei induces crossed-long live protection.PloS one · 2020Article
- Potential of Vitamin E Deficiency, Induced by Inhibition of α-Tocopherol Efflux, in Murine Malaria Infection.International journal of molecular sciences · 2018Review
- Immunization with Transgenic Rodent Malaria Parasites Expressing Pfs25 Induces Potent Transmission-Blocking Activity.Scientific reports · 2018Article
- The Transcription Factor NFAT1 Participates in the Induction of CD4Infection and immunity · 2017Article
- Immunological memory to blood-stage malaria infection is controlled by the histamine releasing factor (HRF) of the parasite.Scientific reports · 2017Article
- Protection against malaria in mice is induced by blood stage-arresting histamine-releasing factor (HRF)-deficient parasites.The Journal of experimental medicine · 2016Article
- Cross-stage immunity for malaria vaccine development.Vaccine · 2015Article
- Disruption of Parasite hmgb2 Gene Attenuates Plasmodium berghei ANKA Pathogenicity.Infection and immunity · 2015Article
- PD-1 deficiency enhances humoral immunity of malaria infection treatment vaccine.Infection and immunity · 2015Article
- Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization.eLife · 2015Article
- Alpha-tocopherol transfer protein gene inhibition enhances the acquired immune response during malaria infection in mice.Parasitology research · 2014Article
- Structural determinants of the 5'-methylthioinosine specificity of Plasmodium purine nucleoside phosphorylase.PloS one · 2014Article
- Plasmodium protease ROM1 is important for proper formation of the parasitophorous vacuole.PLoS pathogens · 2011Article
- Disruption of plasmepsin-4 and merozoites surface protein-7 genes in Plasmodium berghei induces combined virulence-attenuated phenotype.Scientific reports · 2011Article
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5 authors at 3 institutions in 1 country.
Funding
Abstract
Malaria continues to devastate sub-Saharan Africa owing to the emergence of drug resistance to established antimalarials and to the lack of an efficacious vaccine. Plasmodium species have a unique streamlined purine pathway in which the dual specificity enzyme purine nucleoside phosphorylase (PNP) functions in both purine recycling and purine salvage. To evaluate the importance of PNP in an in vivo model of malaria, we disrupted PyPNP, the gene encoding PNP in the lethal Plasmodium yoelii YM strain. P. yoelii parasites lacking PNP were attenuated and cleared in mice. Although able to form gametocytes, PNP-deficient parasites did not form oocysts in mosquito midguts and were not transmitted from mosquitoes to mice. Mice given PNP-deficient parasites were immune to subsequent challenge to a lethal inoculum of P. yoelii YM and to challenge from P. yoelii 17XNL, another strain. These in vivo studies with PNP-deficient parasites support purine salvage as a target for antimalarials. They also suggest a strategy for the development of attenuated nontransmissible metabolic mutants as blood-stage malaria vaccine strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.