ArticleAutophagy2008
Autophagy following heat stress: the role of aging and protein nitration.
Article in Autophagy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Stem cell-based therapeutic strategies for liver aging.Liver research (Beijing, China) · 2025Review
- Biomarkers of aging.Science China. Life sciences · 2023Review
- [Intermittent heat exposure induces thoracic aorta injury in spontaneously hypertensive rats by activating the AMPK/mTOR/ULK1 pathway].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Radiation Hormesis to Improve the Quality of AdultInsects · 2022Article
- Stress-Induced Premature Senescence Related to Oxidative Stress in the Developmental Programming of Nonalcoholic Fatty Liver Disease in a Rat Model of Intrauterine Growth Restriction.Antioxidants (Basel, Switzerland) · 2022Article
- Heat-induced endoplasmic reticulum stress in soleus and gastrocnemius muscles and differential response to UPR pathway in rats.Cell stress & chaperones · 2021Article
- Hallmarks of Aging in the Liver.Computational and structural biotechnology journal · 2019Review
- Heat stress causes dysfunctional autophagy in oxidative skeletal muscle.Physiological reports · 2017Article
- Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in A549 cells.Cell stress & chaperones · 2016Article
- Article
- Effects of mild cold shock (25°C) followed by warming up at 37°C on the cellular stress response.PloS one · 2013Article
- Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis.American journal of physiology. Endocrinology and metabolism · 2012Article
- Mapping the distributions and quantifying the labelling intensities of cell compartments by immunoelectron microscopy: progress towards a coherent set of methods.Journal of anatomy · 2011Review
- Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow.Aging cell · 2011Article
- Autophagy, protein aggregation and hyperthermia: a mini-review.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2011Review
- Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent.Current pharmaceutical design · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Stress can originate from a variety of sources (e.g., physical, chemical, etc.,) and cause protein denaturation, DNA damage and possibly death. In an effort to prevent such deleterious consequences, most organisms possess one or more ways to counteract or even prevent the harmful effect(s) from a given stressor. Such compensation by an organism is known as a stress response; this involves inhibition of housekeeping genes and subsequent activation of genes associated with the stress response. One of the most widely studied groups of stress response genes is a family of molecular chaperones known as heat shock proteins (HSPs). Work from our laboratory agrees with many other studies showing an age-related decline in stress-induced synthesis of HSPs. A decline in the availability and/or function of HSPs with age can lead to accumulation of damaged proteins, which in turn damages cells. Recently, our laboratory found a significant increase in mitochondrial damage as well as evidence of increased autophagy in rat hepatocytes following heat stress. These results, along with findings of increased protein nitration with age, suggest a major role for reactive nitrogen species (RNS) in both the decline in HSP induction and increased hepatocyte pathology observed in old rats following heat stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.