ArticleGenetics2008
Drosophila nemo promotes eye specification directed by the retinal determination gene network.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Modulating the levels and activity of the retinal determination network is sufficient to induce the specification of distinct tissue fates in Drosophila.Development (Cambridge, England) · 2025Article
- Article
- Article
- The Eyes Absent proteins in development and in developmental disorders.Biochemical Society transactions · 2021Review
- The fly eye: Through the looking glass.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- Retinal Expression of the Drosophila eyes absent Gene Is Controlled by Several Cooperatively Acting Cis-regulatory Elements.PLoS genetics · 2016Article
- Article
- Role of the deubiquitylating enzyme DmUsp5 in coupling ubiquitin equilibrium to development and apoptosis in Drosophila melanogaster.PloS one · 2015Article
- Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation.Developmental biology · 2013Article
- Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination.Developmental biology · 2012Article
- MAPK target sites of eyes absent are not required for eye development or survival in Drosophila.PloS one · 2012Article
- A dissection of the teashirt and tiptop genes reveals a novel mechanism for regulating transcription factor activity.Developmental biology · 2011Article
- My what big eyes you have: how the Drosophila retina grows.Developmental neurobiology · 2011Review
- Homodimerization of Nemo-like kinase is essential for activation and nuclear localization.Molecular biology of the cell · 2011Article
- Identification of retinal transformation hot spots in developing Drosophila epithelia.PloS one · 2010Article
- Retinal determination the beginning of eye development.Current topics in developmental biology · 2010Review
- Restriction of ectopic eye formation by Drosophila teashirt and tiptop to the developing antenna.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Differential selection within the Drosophila retinal determination network and evidence for functional divergence between paralog pairs.Evolution & developmentArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila nemo (nmo) is the founding member of the Nemo-like kinase (Nlk) family of serine-threonine kinases. Previous work has characterized nmo's role in planar cell polarity during ommatidial patterning. Here we examine an earlier role for nmo in eye formation through interactions with the retinal determination gene network (RDGN). nmo is dynamically expressed in second and third instar eye imaginal discs, suggesting additional roles in patterning of the eyes, ocelli, and antennae. We utilized genetic approaches to investigate Nmo's role in determining eye fate. nmo genetically interacts with the retinal determination factors Eyeless (Ey), Eyes Absent (Eya), and Dachshund (Dac). Loss of nmo rescues ey and eya mutant phenotypes, and heterozygosity for eya modifies the nmo eye phenotype. Reducing nmo also rescues small-eye defects induced by misexpression of ey and eya in early eye development. nmo can potentiate RDGN-mediated eye formation in ectopic eye induction assays. Moreover, elevated Nmo alone can respecify presumptive head cells to an eye fate by inducing ectopic expression of dac and eya. Together, our genetic analyses reveal that nmo promotes normal and ectopic eye development directed by the RDGN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.