ArticleGenetics2008
A genetic screen identifies new regulators of steroid-triggered programmed cell death in Drosophila.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Evolutionary changes in gene expression profiles associated with the coevolution of male and female genital parts among closely related ground beetle species.BMC genomics · 2022Article
- The Function of Nilaparvata lugens (Hemiptera: Delphacidae) E74 and Its Interaction With βFtz-F1.Journal of insect science (Online) · 2022Article
- Drosophila E93 promotes adult development and suppresses larval responses to ecdysone during metamorphosis.Developmental biology · 2022Article
- Meep, a Novel Regulator of Insulin Signaling, Supports Development and Insulin Sensitivity via Maintenance of Protein Homeostasis inG3 (Bethesda, Md.) · 2020Article
- Drosophila NUAK functions with Starvin/BAG3 in autophagic protein turnover.PLoS genetics · 2020Article
- Ecdysone controlled cell and tissue deletion.Cell death and differentiation · 2020Review
- Article
- A Genetic Screen Using theG3 (Bethesda, Md.) · 2019Article
- Hobbit regulates intracellular trafficking to drive insulin-dependent growth duringDevelopment (Cambridge, England) · 2018Article
- Mutants forG3 (Bethesda, Md.) · 2017Article
- Septate Junction Proteins Play Essential Roles in Morphogenesis Throughout Embryonic Development in Drosophila.G3 (Bethesda, Md.) · 2016Article
- Genomic and Transcriptomic Associations Identify a New Insecticide Resistance Phenotype for the Selective Sweep at the Cyp6g1 Locus of Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
- Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner.EMBO reports · 2016Article
- CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.PLoS biology · 2015Article
- Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila.Developmental biology · 2015Article
- INO80-dependent regression of ecdysone-induced transcriptional responses regulates developmental timing in Drosophila.Developmental biology · 2014Article
- Article
- Macroglobulin complement-related encodes a protein required for septate junction organization and paracellular barrier function in Drosophila.Development (Cambridge, England) · 2014Article
- Rapid recombination mapping for high-throughput genetic screens in Drosophila.G3 (Bethesda, Md.) · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The steroid hormone ecdysone triggers the rapid and massive destruction of larval tissues through transcriptional cascades that culminate in rpr and hid expression and caspase activation. Here we describe the use of genetic screens to further our understanding of this steroid-triggered programmed cell death response. Pupal lethal mutants were screened for specific defects in larval salivary gland destruction. A pilot screen using existing P-element collections resulted in the identification of mutations in known cell death regulators, E74 and hid, as well as multiple alleles in CBP (nejire) and dTrf2. A large-scale EMS mutagenesis screen on the third chromosome resulted in the recovery of 48 mutants. These include seven multiallelic complementation groups, at least five of which do not map to regions or genes previously associated with cell death. Five mutants display defects in the transcriptional induction of rpr and hid, and all display a penetrant block in caspase activation. Three were mapped to specific genes: CG5146, which encodes a protein of unknown function, Med24, which encodes a component of the RNA polymerase II mediator complex, and CG7998, which encodes a putative mitochondrial malate dehydrogenase. These genetic screens provide new directions for understanding the regulation of programmed cell death during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.