ArticleGenetics2008
The phenomics and expression quantitative trait locus mapping of brain transcriptomes regulating adaptive divergence in lake whitefish species pairs (Coregonus sp.).
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Pooled it
- Neural divergence and hybrid disruption between ecologically isolatedProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Transcriptomic comparison reveals genetic variation potentially underlying seed developmental evolution of soybeans.Journal of experimental botany · 2018Article
- Regulatory Architecture of Gene Expression Variation in the Threespine Stickleback Gasterosteus aculeatus.G3 (Bethesda, Md.) · 2017Article
- Domestication drive the changes of immune and digestive system of Eurasian perch (Perca fluviatilis).PloS one · 2017Article
- Genomic architecture of phenotypic divergence between two hybridizing plant species along an elevational gradient.AoB PLANTS · 2016Article
- RAD-QTL Mapping Reveals Both Genome-Level Parallelism and Different Genetic Architecture Underlying the Evolution of Body Shape in Lake Whitefish (Coregonus clupeaformis) Species Pairs.G3 (Bethesda, Md.) · 2015Article
- Transcriptomics of salinity tolerance capacity in Arctic charr (Salvelinus alpinus): a comparison of gene expression profiles between divergent QTL genotypes.Physiological genomics · 2014Article
- Differences in brain transcriptomes of closely related Baikal coregonid species.BioMed research international · 2014Article
- Linking transcriptomic and genomic variation to growth in brook charr hybrids (Salvelinus fontinalis, Mitchill).Heredity · 2013Article
- Brain transcriptome variation among behaviorally distinct strains of zebrafish (Danio rerio).BMC genomics · 2012Article
- Genome-wide patterns of divergence during speciation: the lake whitefish case study.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Article
- Regulatory versus coding signatures of natural selection in a candidate gene involved in the adaptive divergence of whitefish species pairs (Coregonus spp.).Ecology and evolution · 2012Article
- Ecological transcriptomics of lake-type and riverine sockeye salmon (Oncorhynchus nerka).BMC ecology · 2011Article
- Article
- Systems genetics, bioinformatics and eQTL mapping.Genetica · 2010Review
- The role of gene expression in ecological speciation.Annals of the New York Academy of Sciences · 2010Review
- Speciation genetics: current status and evolving approaches.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- On the origin of species: insights from the ecological genomics of lake whitefish.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Expression quantitative trait loci are highly sensitive to cellular differentiation state.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used microarrays and a previously established linkage map to localize the genetic determinants of brain gene expression for a backcross family of lake whitefish species pairs (Coregonus sp.). Our goals were to elucidate the genomic distribution and sex specificity of brain expression QTL (eQTL) and to determine the extent to which genes controlling transcriptional variation may underlie adaptive divergence in the recently evolved dwarf (limnetic) and normal (benthic) whitefish. We observed a sex bias in transcriptional genetic architecture, with more eQTL observed in males, as well as divergence in genome location of eQTL between the sexes. Hotspots of nonrandom aggregations of up to 32 eQTL in one location were observed. We identified candidate genes for species pair divergence involved with energetic metabolism, protein synthesis, and neural development on the basis of colocalization of eQTL for these genes with eight previously identified adaptive phenotypic QTL and four previously identified outlier loci from a genome scan in natural populations. Eighty-eight percent of eQTL-phenotypic QTL colocalization involved growth rate and condition factor QTL, two traits central to adaptive divergence between whitefish species pairs. Hotspots colocalized with phenotypic QTL in several cases, revealing possible locations where master regulatory genes, such as a zinc-finger protein in one case, control gene expression directly related to adaptive phenotypic divergence. We observed little evidence of colocalization of brain eQTL with behavioral QTL, which provides insight into the genes identified by behavioral QTL studies. These results extend to the transcriptome level previous work illustrating that selection has shaped recent parallel divergence between dwarf and normal lake whitefish species pairs and that metabolic, more than morphological, differences appear to play a key role in this divergence.
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