ArticleGenetics2008
A genomewide linkage scan for quantitative trait loci influencing the craniofacial complex in baboons (Papio hamadryas spp.).
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology.PLoS genetics · 2016Pooled it
- Quantitative Genetic Analysis of Baboon Facial Variation Challenges a Classic Papionin Trait.Integrative organismal biology (Oxford, England) · 2026Article
- Article
- Genetic influences on dentognathic morphology in the Jirel population of Nepal.Anatomical record (Hoboken, N.J. : 2007) · 2022Article
- Accurate assembly of the olive baboon (Papio anubis) genome using long-read and Hi-C data.GigaScience · 2020Article
- Genetic contributions to dental dimensions in brown-mantled tamarins (Saguinus fuscicollis) and rhesus macaques (Macaca mulatta).American journal of physical anthropology · 2019Article
- Genetics of murine craniofacial morphology: diallel analysis of the eight founders of the Collaborative Cross.Journal of anatomy · 2016Article
- Article
- Heritability of the Human Craniofacial Complex.Anatomical record (Hoboken, N.J. : 2007) · 2015Article
- Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.Frontiers in physiology · 2015Article
- Baboons as a model to study genetics and epigenetics of human disease.ILAR journal · 2013Review
- The baboon kidney transcriptome: analysis of transcript sequence, splice variants, and abundance.PloS one · 2013Article
- Genome-wide association study of three-dimensional facial morphology identifies a variant in PAX3 associated with nasion position.American journal of human genetics · 2012Article
- Nasal bone shape is under complex epistatic genetic control in mouse interspecific recombinant congenic strains.PloS one · 2012Article
- Genetic and environmental contributions to variation in baboon cranial morphology.American journal of physical anthropology · 2010Article
- Evolutionary genetics in wild primates: combining genetic approaches with field studies of natural populations.Trends in genetics : TIG · 2010Review
- How genomics has informed our understanding of the pathogenesis of osteoporosis.Genome medicine · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Numerous studies have detected significant contributions of genes to variation in development, size, and shape of craniofacial traits in a number of vertebrate taxa. This study examines 43 quantitative traits derived from lateral cephalographs of 830 baboons (Papio hamadryas) from the pedigreed population housed at the Southwest National Primate Research Center. Quantitative genetic analyses were conducted using the SOLAR analytic platform, a maximum-likelihood variance components method that incorporates all familial information for parameter estimation. Heritability estimates were significant and of moderate to high magnitude for all craniofacial traits. Additionally, 14 significant quantitative trait loci (QTL) were identified for 12 traits from the three developmental components (basicranium, splanchnocranium, and neurocranium) of the craniofacial complex. These QTL were found on baboon chromosomes (and human orthologs) PHA1 (HSA1), PHA 2 (HSA3), PHA4 (HSA6), PHA11 (HSA12), PHA13 (HSA2), PHA16 (HSA17), and PHA17 (HSA13) (PHA, P. hamadryas; HSA, Homo sapiens). This study of the genetic architecture of the craniofacial complex in baboons provides the groundwork needed to establish the baboon as an animal model for the study of genetic and nongenetic influences on craniofacial variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.