ArticleObstetrics and gynecology2008
Midpregnancy vaginal fluid defensins, bacterial vaginosis, and risk of preterm delivery.
Article in Obstetrics and gynecology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Defensins: defenders of human reproductive health.Human reproduction update · 2023Review
- The Role of Antimicrobial Peptides in Preterm Birth.International journal of molecular sciences · 2021Review
- Associations of public water system trihalomethane exposure during pregnancy with spontaneous preterm birth and the cervicovaginal microbial-immune state.Environmental research · 2021Article
- Mutual Preservation: A Review of Interactions Between Cervicovaginal Mucus and Microbiota.Frontiers in cellular and infection microbiology · 2021Review
- Bacterial vaginosis and the cervicovaginal immune response.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Review
- Associations between vaginal bacteria and levels of vaginal defensins in pregnant women.American journal of obstetrics and gynecology · 2013Article
- Association of bactericidal activity of genital tract secretions with Escherichia coli colonization in pregnancy.American journal of obstetrics and gynecology · 2012Article
- Innate immunity in the human female reproductive tract: endocrine regulation of endogenous antimicrobial protection against HIV and other sexually transmitted infections.American journal of reproductive immunology (New York, N.Y. : 1989) · 2011Review
- Midpregnancy levels of angiogenic markers in relation to maternal characteristics.American journal of obstetrics and gynecology · 2011Article
- Use of cervicovaginal fluid for the identification of biomarkers for pathologies of the female genital tract.Proteome science · 2010Article
- Evidence for activation of Toll-like receptor and receptor for advanced glycation end products in preterm birth.Mediators of inflammation · 2010Review
- Differential expression pattern of genes encoding for anti-microbial peptides in the fetal membranes of patients with spontaneous preterm labor and intact membranes and those with preterm prelabor rupture of the membranes.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo assess relations among midpregnancy vaginal defensin levels, a component of the host innate immune response, bacterial vaginosis, and risk of preterm delivery. These relations are compared across race groups because previous studies have repeatedly shown that the prevalence of bacterial vaginosis and the risk of preterm delivery are greater in African-American women compared with that in white women.
methodsData are from a prospective study that enrolled pregnant women from 52 clinics in five Michigan communities. In the study subcohort, defensins (human neutrophil peptides 1, 2 and 3) and bacterial vaginosis (Nugent criteria) were measured in vaginal fluid collected at enrollment (15th through 27th week of pregnancy) from 1,031 non-Hispanic white and African-American women (787 term, 244 preterm). Preterm deliveries were categorized by clinical circumstances, ie, spontaneous and medically indicated.
resultsAmong African Americans, vaginal human neutrophil peptides 1-3 levels greater than or equal to the median were associated with bacterial vaginosis and specifically with spontaneous preterm delivery only (adjusted odds ratio 2.3, 95% confidence interval 1.2-4.3). Once African-American women were stratified by human neutrophil peptide 1-3 levels, bacterial vaginosis added nothing to the prediction of spontaneous preterm delivery risk. None of the above associations were observed in non-Hispanic whites.
conclusionThe relations among human neutrophil peptide 1-3 levels, bacterial vaginosis, and preterm delivery vary by race group. In African Americans, midpregnancy human neutrophil peptide 1-3 levels were more informative to preterm delivery risk than was bacterial vaginosis, suggesting an important role for host response. In addition, elevated human neutrophil peptide 1-3 levels may be a marker for particular high-risk vaginal milieus that are not distinguished by the current bacterial vaginosis Nugent scoring system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.