ArticleApplied and environmental microbiology2008
Heme uptake by Microscilla marina and evidence for heme uptake systems in the genomes of diverse marine bacteria.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
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- Whole-Cell Biosensor for Iron Monitoring as a Potential Tool for Safeguarding Biodiversity in Polar Marine Environments.Marine drugs · 2024Review
- Iron limitation of heterotrophic bacteria in the California Current System tracks relative availability of organic carbon and iron.The ISME journal · 2024Article
- Two TonB-dependent outer membrane transporters involved in heme uptake inMicrobial cell (Graz, Austria) · 2024Article
- A Black Raspberry-Rich Diet Protects From Dextran Sulfate Sodium-Induced Intestinal Inflammation and Host Metabolic Perturbation in Association With Increased Aryl Hydrocarbon Receptor Ligands in the Gut Microbiota of Mice.Frontiers in nutrition · 2022Article
- Biosynthesis of Tetrapyrrole Cofactors by Bacterial Community Inhabiting Porphyrine-Containing Shale Rock (Fore-Sudetic Monocline).Molecules (Basel, Switzerland) · 2021Article
- Iron Uptake Mechanisms in Marine Phytoplankton.Frontiers in microbiology · 2020Review
- Phenomics and Genomics Reveal Adaptation ofFrontiers in microbiology · 2019Article
- Abundance of the iron containing biomolecule, heme b, during the progression of a spring phytoplankton bloom in a mesocosm experiment.PloS one · 2017Article
- Quantifying Integrated Proteomic Responses to Iron Stress in the Globally Important Marine Diazotroph Trichodesmium.PloS one · 2015Article
- Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Utilization of heme as an iron source by marine Alphaproteobacteria in the Roseobacter clade.Applied and environmental microbiology · 2013Article
- Insights on how the Mycobacterium tuberculosis heme uptake pathway can be used as a drug target.Future medicinal chemistry · 2013Article
- The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11.The Journal of biological chemistry · 2013Article
- How protein targeting to primary plastids via the endomembrane system could have evolved? A new hypothesis based on phylogenetic studies.Biology direct · 2013Article
- Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica.Nature communications · 2013Article
- Marine crude-oil biodegradation: a central role for interspecies interactions.Aquatic biosystems · 2012Article
- Analysis of the global ocean sampling (GOS) project for trends in iron uptake by surface ocean microbes.PloS one · 2012Article
- Factors influencing the diversity of iron uptake systems in aquatic microorganisms.Frontiers in microbiology · 2012Article
- Genomics of the proteorhodopsin-containing marine flavobacterium Dokdonia sp. strain MED134.Applied and environmental microbiology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to acquire diverse and abundant forms of iron would be expected to confer a survival advantage in the marine environment, where iron is scarce. Marine bacteria are known to use siderophores and inorganic iron, but their ability to use heme, an abundant intracellular iron form, has only been examined preliminarily. Microscilla marina, a cultured relative of a bacterial group frequently found on marine particulates, was used as a model organism to examine heme uptake. Searches of the genome revealed analogs to known heme transport proteins, and reverse transcription-quantitative PCR analysis of these genes showed that they were expressed and upregulated under iron stress and during growth on heme. M. marina was found to take up heme-bound iron and could grow on heme as a sole iron source, supporting the genetic evidence for heme transport. Similar putative heme transport components were identified in the genomes of diverse marine bacteria. These systems were found in the genomes of many bacteria thought to be particle associated but were lacking in known free-living organisms (e.g., Pelagibacter ubique and marine cyanobacteria). This distribution of transporters is consistent with the hydrophobic, light-sensitive nature of heme, suggesting that it is primarily available on phytoplankton or detritus or in nutrient-rich environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.