ArticleJournal of bacteriology2008
Systematic identification and sequence analysis of the genomic islands of the enteropathogenic Escherichia coli strain B171-8 by the combined use of whole-genome PCR scanning and fosmid mapping.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Genome on the move: emergence of hybrid atypical enteropathogenic/enteroaggregativeMicrobiology spectrum · 2026Article
- Comparative genomic analysis provides insight into the phylogeny and virulence of atypical enteropathogenic Escherichia coli strains from Brazil.PLoS neglected tropical diseases · 2020Article
- Article
- Genomic Properties and Temporal Analysis of the Interaction of an InvasiveFrontiers in cellular and infection microbiology · 2020Article
- Genomic Characterization of β-Glucuronidase-Positive Escherichia coli O157:H7 Producing Stx2a.Emerging infectious diseases · 2018Article
- Evolution of atypical enteropathogenic E. coli by repeated acquisition of LEE pathogenicity island variants.Nature microbiology · 2016Article
- The Shiga toxin 2 production level in enterohemorrhagic Escherichia coli O157:H7 is correlated with the subtypes of toxin-encoding phage.Scientific reports · 2015Article
- Defining the Genome Features of Escherichia albertii, an Emerging Enteropathogen Closely Related to Escherichia coli.Genome biology and evolution · 2015Article
- A novel family of integrases associated with prophages and genomic islands integrated within the tRNA-dihydrouridine synthase A (dusA) gene.Nucleic acids research · 2015Article
- The arable ecosystem as battleground for emergence of new human pathogens.Frontiers in microbiology · 2014Review
- Refining the pathovar paradigm via phylogenomics of the attaching and effacing Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Quantitative proteomic analysis of type III secretome of enteropathogenic Escherichia coli reveals an expanded effector repertoire for attaching/effacing bacterial pathogens.Molecular & cellular proteomics : MCP · 2012Article
- Genetic background and mobility of variants of the gene nleA in attaching and effacing Escherichia coli.Applied and environmental microbiology · 2011Article
- Virulence gene profiling of enterohemorrhagic (EHEC) and enteropathogenic (EPEC) Escherichia coli strains: a basis for molecular risk assessment of typical and atypical EPEC strains.BMC microbiology · 2011Article
- NleC, a type III secretion protease, compromises NF-κB activation by targeting p65/RelA.PLoS pathogens · 2010Article
- A comprehensive proteomic analysis of the type III secretome of Citrobacter rodentium.The Journal of biological chemistry · 2010Article
- Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Inference of the impact of insertion sequence (IS) elements on bacterial genome diversification through analysis of small-size structural polymorphisms in Escherichia coli O157 genomes.Genome research · 2009Article
- Comparative analysis of the locus of enterocyte effacement and its flanking regions.Infection and immunity · 2009Article
- Distribution of espM and espT among enteropathogenic and enterohaemorrhagic Escherichia coli.Journal of medical microbiology · 2009Article
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Authors and funding
12 authors.
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Abstract
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) are diarrheagenic pathogens that colonize the intestinal tract through the formation of attaching and effacing lesions, induced by effectors translocated via a type III secretion system (T3SS) encoded on the locus of enterocyte effacement (LEE). In EHEC O157, numerous virulence factors, including around 40 T3SS effectors, have been identified. Most of them are encoded on genomic islands (GEIs) such as prophages and integrative elements. For EPEC, however, no systematic search of GEIs and virulence-related genes carried therein has been done, and only a limited number of virulence factors have been identified so far. In this study, we performed a systemic and genome-wide survey of the GEIs in strain B171-8, one of the prototype strains of EPEC, by the combined use of whole-genome PCR scanning and fosmid mapping and identified 22 large GEIs, including nine lambda-like prophages, three P2-like prophages, the LEE, and three additional integrative elements. On these prophages and integrative elements, we found genes for a set of T3SS proteins, a total of 33 T3SS effectors or effector homologues, and 12 other virulence factors which include five nonfimbrial adhesins. Most of the T3SS effector families identified are also present in EHEC O157, but B171-8 possesses a significantly smaller number of effectors. Not only the presence or absence of Shiga toxin genes but also the difference in the T3SS effector repertoire should be considered in analyzing the pathogenicity of EPEC and EHEC strains.
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