ArticleJournal of bacteriology2008
Abundance changes of the response regulator RcaC require specific aspartate and histidine residues and are necessary for normal light color responsiveness.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Multispectral regulation of chromatic acclimation by integration of the Rca system and the conservedJournal of bacteriology · 2026Article
- Reflections on Cyanobacterial Chromatic Acclimation: Exploring the Molecular Bases of Organismal Acclimation and Motivation for Rethinking the Promotion of Equity in STEM.Microbiology and molecular biology reviews : MMBR · 2022Review
- A hybrid type of chromatic acclimation regulated by the dual green/red photosensory systems in cyanobacteria.Plant physiology · 2022Article
- The Red Edge: Bilin-Binding Photoreceptors as Optogenetic Tools and Fluorescence Reporters.Chemical reviews · 2021Review
- DEG9, a serine protease, modulates cytokinin and light signaling by regulating the level of ARABIDOPSIS RESPONSE REGULATOR 4.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Conditional, temperature-induced proteolytic regulation of cyanobacterial RNA helicase expression.Journal of bacteriology · 2014Article
- SCF(KMD) controls cytokinin signaling by regulating the degradation of type-B response regulators.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Green/red cyanobacteriochromes regulate complementary chromatic acclimation via a protochromic photocycle.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Temporal responses of wild-type pigmentation and RcaE-deficient strains of Fremyella diplosiphon during light transitions.Communicative & integrative biology · 2011Article
- Independence and interdependence of the photoregulation of pigmentation and development in Fremyella diplosiphon.Communicative & integrative biology · 2010Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RcaC is a large, complex response regulator that controls transcriptional responses to changes in ambient light color in the cyanobacterium Fremyella diplosiphon. The regulation of RcaC activity has been shown previously to require aspartate 51 and histidine 316, which appear to be phosphorylation sites that control the DNA binding activity of RcaC. All available data suggest that during growth in red light, RcaC is phosphorylated and has relatively high DNA binding activity, while during growth in green light RcaC is not phosphorylated and has less DNA binding activity. RcaC has also been found to be approximately sixfold more abundant in red light than in green light. Here we demonstrate that the light-controlled abundance changes of RcaC are necessary, but not sufficient, to direct normal light color responses. RcaC abundance changes are regulated at both the RNA and protein levels. The RcaC protein is significantly less stable in green light than in red light, suggesting that the abundance of this response regulator is controlled at least in part by light color-dependent proteolysis. We provide evidence that the regulation of RcaC abundance does not depend on any RcaC-controlled process but rather depends on the presence of the aspartate 51 and histidine 316 residues that have previously been shown to control the activity of this protein. We propose that the combination of RcaC abundance changes and modification of RcaC by phosphorylation may be necessary to provide the dynamic range required for transcriptional control of RcaC-regulated genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.