Evidence map›Paper›PMID 18757407›Full record

ArticleCancer research2008

A stochastic model for cancer stem cell origin in metastatic colon cancer.

Christine Odoux, Helene Fohrer, Toshitaka Hoppo, Lynda Guzik, Donna Beer Stolz, Dale W Lewis, Susanne M Gollin, T Clark Gamblin, David A Geller, Eric Lagasse

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  5. Review
  6. Review
  7. Review
  8. Article
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  10. Article
  11. Review
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  13. Review
  14. JNK Signaling in Stem Cell Self-Renewal and Differentiation.International journal of molecular sciences · 2020
    Review
  15. Metabolic Adaptations in Cancer Stem Cells.Frontiers in oncology · 2020
    Review
  16. Review
  17. Cell communication and signaling : CCS · 2019
    Article
  18. Review
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Christine OdouxMcGowan Institute for Regenerative Medicine, Department of Pathology, University of Pittsburgh Medical School, 100 Technology Drive, Suite 200, Pittsburgh PA, 15219-3130, USA.
Helene Fohrer
Toshitaka Hoppo
Lynda Guzik
Donna Beer Stolz
Dale W Lewis
Susanne M Gollin
T Clark Gamblin
David A Geller
Eric Lagasse
McGowan Institute for Regenerative Medicine · USUniversity of Pittsburgh Medical Center · USUPMC Hillman Cancer Center · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Characterization of the 11q13 Amplicon in Oral CancerR01DE014729 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOLLIN, SUSANNE M · 2002 to 2006
$1.7M
NCATS NIH HHS UL1 TR000005NCI NIH HHS P30 CA047904NCI NIH HHS P30CA047904NIDCR NIH HHS R01 DE014729NIDCR NIH HHS R01DE14729
6 · The paper itself

Abstract

Human cancers have been found to include transformed stem cells that may drive cancer progression to metastasis. Here, we report that metastatic colon cancer contains clonally derived tumor cells with all of the critical properties expected of stem cells, including self-renewal and the ability to differentiate into mature colon cells. Additionally, when injected into mice, these cells initiated tumors that closely resemble human cancer. Karyotype analyses of parental and clonally derived tumor cells expressed many consistent (clonal) along with unique chromosomal aberrations, suggesting the presence of chromosomal instability in the cancer stem cells. Thus, this new model for cancer origin and metastatic progression includes features of both the hierarchical model for cancerous stem cells and the stochastic model, driven by the observation of chromosomal instability.

Indexed as

Neoplasm MetastasisStochastic ProcessesAgedAged, 80 and overAnimalsColorectal NeoplasmsFemaleHumansMaleMiceMice, KnockoutMicroscopy, Electron, TransmissionMiddle AgedNeoplastic Stem Cells

Identifiers

PMID18757407
PMCPMC2562348
OpenAlexW2129448921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.