ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2008
Patient education level as a predictor of survival in lung cancer clinical trials.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Prevalence and risk factors of sleep disturbances among patients with lung cancer: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- A systematic review of the impact of pain on overall survival in patients with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Pooled it
- Educational attainment and employment status in lung cancer patients: a nationwide study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Lung Cancer in Women-Sociodemographic, Clinical and Psychological Characteristics with Comparison to Men.Journal of clinical medicine · 2024Article
- Review
- Smoking and BMI mediate the causal effect of education on lower back pain: observational and Mendelian randomization analyses.Frontiers in endocrinology · 2024Observational
- The Role of Sublobar Resection for the Surgical Treatment of Non-Small Cell Lung Cancer.Current oncology (Toronto, Ont.) · 2023Review
- Statistical Inference for Cox Proportional Hazards Models with a Diverging Number of Covariates.Scandinavian journal of statistics, theory and applications · 2023Article
- Social determinants of health and lung cancer surgery: a qualitative study.Frontiers in public health · 2023Article
- The cancer survival index-A prognostic score integrating psychosocial and biological factors in patients diagnosed with cancer or haematologic malignancies.Cancer medicine · 2022Article
- Impact of socioeconomic status on cancer staging, survival in non-small cell lung cancer.Frontiers in public health · 2022Article
- Overall survival with warfarin vs. low-molecular-weight heparin in cancer-associated thrombosis.Journal of thrombosis and haemostasis : JTH · 2021Article
- Association of Race, Socioeconomic Factors, and Treatment Characteristics With Overall Survival in Patients With Limited-Stage Small Cell Lung Cancer.JAMA network open · 2021Article
- Survival of Black and White Patients With Stage IV Small Cell Lung Cancer.Frontiers in oncology · 2021Article
- Article
- Predictors of health-related quality of life in Chinese patients receiving treatment for neovascular age-related macular degeneration: a prospective longitudinal study.BMC ophthalmology · 2020Article
- Racial/ethnic differences in survival for patients with gliosarcoma: an analysis of the National cancer database.Journal of neuro-oncology · 2019Article
- Socio-demographic, Clinical, and Genetic Determinants of Quality of Life in Lung Cancer Patients.Scientific reports · 2018Article
- Socioeconomic Differences and Lung Cancer Survival-Systematic Review and Meta-Analysis.Frontiers in oncology · 2018Article
- Effect of socioeconomic status as measured by education level on survival in breast cancer clinical trials.Psycho-oncology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo investigate the effect of socioeconomic status, as measured by education, on the survival of 1,577 lung cancer patients treated on 11 studies conducted by the Cancer and Leukemia Group B. PATIENTS AND
methodsSociodemographic data, including education, was reported by the patient at the time of clinical trial accrual. Cox proportional hazards model stratified by treatment arm/study was used to examine the effect of education on survival after adjustment for known prognostic factors.
resultsThe patient population included 1,177 patients diagnosed with non-small-cell lung cancer (NSCLC; stage III or IV) and 400 patients diagnosed with small-cell lung cancer (SCLC; extensive or limited). Patients with less than an eighth grade education (13% of patients) were significantly more likely to be male, nonwhite, and older; have a performance status (PS) of 1 or 2; and have chest pain. Significant predictors of poor survival in the final model included male sex, PS of 1 or 2, dyspnea, weight loss, liver or bone metastases, unmarried, presence of adrenal metastases and high alkaline phosphatase levels among patients with NSCLC, and high WBC levels among patients with advanced disease. Education was not predictive of survival.
conclusionThe physical condition of patients with low education who enroll onto clinical trials is worse than patients with higher education. Once enrolled onto a clinical trial, education does not affect the survival of patients with SCLC or stage III or IV NSCLC. The standardization of treatment and follow-up within a clinical trial, regardless of education, is one possible explanation for this lack of effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.