Evidence map›Paper›PMID 18757292›Full record

ReviewArteriosclerosis, thrombosis, and vascular biology2008

Chemokines as mediators of neovascularization.

Ellen C Keeley, Borna Mehrad, Robert M Strieter

Open access · bronzeAbstract readReview
In one paragraph

Review in Arteriosclerosis, thrombosis, and vascular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 191 citations in OpenAlex.

  1. Inflammatory Biomarkers in Diabetic Macular Edema.Journal of clinical medicine · 2026
    Review
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  10. PGFEMBO molecular medicine · 2023
    Article
  11. CXCL5 gene polymorphisms and coronary collateralization.American heart journal plus : cardiology research and practice · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ellen C KeeleyDepartment of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA 22908-0466, USA.
Borna Mehrad
Robert M Strieter
University of Virginia · US

Funding

CXC Chemokines in CancerR01CA087879 · NCI · UNIVERSITY OF VIRGINIA · PI STRIETER, ROBERT M · 2000 to 2010
$3.4M
NK cells in host defense against invasive aspergillosisR01HL073848 · NHLBI · UNIVERSITY OF VIRGINIA · PI MEHRAD, BORNA · 2003 to 2013
$3.3M
Chemokines and Fibrocytes in Acute Lung InjuryR01HL066027 · NHLBI · UNIVERSITY OF VIRGINIA · PI STRIETER, ROBERT M · 2001 to 2009
$3.2M
NCI NIH HHS CA87879NCI NIH HHS R01 CA087879NHLBI NIH HHS HL66027NHLBI NIH HHS HL73848NHLBI NIH HHS R01 HL066027NHLBI NIH HHS R01 HL073848
6 · The paper itself

Abstract

Chemokines are a superfamily of homologous heparin-binding proteins, first described for their role in recruiting leukocytes to sites of inflammation. Chemokines have since been recognized as key factors mediating both physiological and pathological neovascularization in such diverse clinical settings as malignancy, wound repair, chronic fibroproliferative disorders, myocardial ischemia, and atherosclerosis. Members of the CXC chemokine family, structurally defined as containing the ELR amino acid motif, are potent inducers of angiogenesis, whereas another subset of the CXC chemokines inhibits angiogenesis. In addition, CCL2, a CC chemokine ligand, has been implicated in arteriogenesis. In this article, we review the current literature on the role of chemokines as mediators of neovascularization.

Indexed as

Angiogenic ProteinsAngiostatic ProteinsAnimalsChemokinesEndothelial CellsHumansNeovascularization, PathologicNeovascularization, PhysiologicAngiogenic ProteinsAngiostatic ProteinsChemokines

Identifiers

PMID18757292
PMCPMC2735456
OpenAlexW2125050685

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.