ArticleThe EMBO journal2008
The SpoMBe pathway drives membrane bending necessary for cytokinesis and spore formation in yeast meiosis.
Article in The EMBO journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Transcriptome profiling of Saccharomyces cerevisiae under 3-bromopyruvate treatment.Journal of applied genetics · 2026Article
- Remodeling of the secretory pathway is coordinated withiScience · 2024Article
- Meiotic Cytokinesis inJournal of fungi (Basel, Switzerland) · 2024Review
- The distribution of phosphatidylinositol 4,5-bisphosphate in the budding yeast plasma membrane.Histochemistry and cell biology · 2021Article
- The Smk1 MAPK and Its Activator, Ssp2, Are Required for Late Prospore Membrane Development in SporulatingJournal of fungi (Basel, Switzerland) · 2021Article
- Ndt80 activates the meiotic ORC1 transcript isoform and SMA2 via a bi-directional middle sporulation element in Saccharomyces cerevisiae.RNA biology · 2016Article
- The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.Microbiology and molecular biology reviews : MMBR · 2016Review
- SPO73 and SPO71 Function Cooperatively in Prospore Membrane Elongation During Sporulation in Saccharomyces cerevisiae.PloS one · 2015Article
- Transcriptome structure variability in Saccharomyces cerevisiae strains determined with a newly developed assembly software.BMC genomics · 2014Article
- A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast.Eukaryotic cell · 2014Article
- Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror.Developmental biology · 2013Article
- Dual function of the NDR-kinase Dbf2 in the regulation of the F-BAR protein Hof1 during cytokinesis.Molecular biology of the cell · 2013Article
- SPO71 mediates prospore membrane size and maturation in Saccharomyces cerevisiae.Eukaryotic cell · 2012Article
- Sporulation in the budding yeast Saccharomyces cerevisiae.Genetics · 2011Review
- Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis.Genes & development · 2011Article
- Efficient protein depletion by genetically controlled deprotection of a dormant N-degron.Molecular systems biology · 2009Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Precise control over organelle shapes is essential for cellular organization and morphogenesis. During yeast meiosis, prospore membranes (PSMs) constitute bell-shaped organelles that enwrap the postmeiotic nuclei leading to the cellularization of the mother cell's cytoplasm and to spore formation. Here, we analysed how the PSMs acquire their curved bell-shaped structure. We discovered that two antagonizing forces ensure PSM shaping and proper closure during cytokinesis. The Ssp1p-containing coat at the leading edge of the PSM generates a pushing force, which is counteracted by a novel pathway, the spore membrane-bending pathway (SpoMBe). Using genetics, we found that Sma2p and Spo1p, a phospholipase, as well as several GPI-anchored proteins belong to the SpoMBe pathway. They exert a force all along the membrane, responsible for membrane bending during PSM biogenesis and for PSM closure during cytokinesis. We showed that the SpoMBe pathway involves asymmetric distribution of Sma2p and does not involve a GPI-protein-containing matrix. Rather, repulsive forces generated by asymmetrically distributed and dynamically moving GPI-proteins are suggested as the membrane-bending principle.
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