ArticleGut2008
Miniprobe confocal laser microscopy for the detection of invisible neoplasia in patients with Barrett's oesophagus.
Article in Gut, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Comparison Between Probe-based Confocal Laser Endomicroscopy, White-light Endoscopy and Virtual Chromoendoscopy for the Diagnosis of Gastric Pre-neoplastic and Neoplastic Lesions (pCLE-GCEP)
Clinical Evaluation Of NCLE in The Lymph Nodes Along With Masses and Cystic Tumors of the Pancreas
Registry Trial to Determine pCLE Image Interpretation Criteria and Preliminary Accuracy: Discrete Pulmonary Lesions and Acute Rejection in Transplanted Lungs
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 209 citations in OpenAlex.
- Confocal Laser Endomicroscopy in Gastrointestinal and Pancreatobiliary Diseases: A Systematic Review and Meta-Analysis.BioMed research international · 2016Pooled it
- Probe-based confocal laser endomicroscopy versus biopsies in the diagnostics of oesophageal and gastric lesions: A prospective, pathologist-blinded study.United European gastroenterology journal · 2020Trial
- Comparison of probe-based confocal endomicroscopy with virtual chromoendoscopy and white-light endoscopy for diagnosis of gastric intestinal metaplasia.Surgical endoscopy · 2013Trial
- Probe-based confocal laser microscopy identifies criteria predictive of active celiac sprue.Digestive diseases and sciences · 2012Trial
- Real-time increased detection of neoplastic tissue in Barrett's esophagus with probe-based confocal laser endomicroscopy: final results of an international multicenter, prospective, randomized, controlled trial.Gastrointestinal endoscopy · 2011Trial
- Confocal laser endomicroscopy in Barrett's esophagus and endoscopically inapparent Barrett's neoplasia: a prospective, randomized, double-blind, controlled, crossover trial.Gastrointestinal endoscopy · 2009Trial
- Confocal laser endomicroscopy for upper gastrointestinal neoplasia: Systematic review and meta-analysis.Endoscopy international open · 2026Article
- Review
- Advanced endoscopic imaging for detection of Barrett's esophagus.Clinical endoscopy · 2024Review
- Flexible endoscopic instrument for diagnosis and treatment of early gastric cancer.Medical & biological engineering & computing · 2023Review
- Optical Biopsy of Dysplasia in Barrett's Oesophagus Assisted by Artificial Intelligence.Cancers · 2023Article
- Development of Advanced Imaging and Molecular Imaging for Barrett's Neoplasia.Diagnostics (Basel, Switzerland) · 2022Review
- Advances in Pediatric Diagnostic Endoscopy: A State-of-the-Art Review.JPGN reports · 2022Review
- The Use of Confocal Laser Endomicroscopy in Diagnosing Barrett's Esophagus and Esophageal Adenocarcinoma.Diagnostics (Basel, Switzerland) · 2022Review
- Endoscopic Diagnosis and Management of Barrett's Esophagus with Low-Grade Dysplasia.Diagnostics (Basel, Switzerland) · 2022Review
- Fluorescence-guided fiber-optic micronavigation using microscopic identification of vascular boundary of liver segment and tumors.Theranostics · 2020Article
- Advanced imaging in surveillance of Barrett's esophagus: Is the juice worth the squeeze?World journal of gastroenterology · 2019Review
- Advanced endoscopic methods in gastrointestinal diseases: a systematic review.Quantitative imaging in medicine and surgery · 2019Review
- Probe-Based Confocal Laser Endomicroscopy During Transurethral Resection of Bladder Tumors Improves the Diagnostic Accuracy and Therapeutic Efficacy.Annals of surgical oncology · 2019Article
- Fluorescein as a topical fluorescent contrast agent for quantitative microendoscopic inspection of colorectal epithelium.Biomedical optics express · 2017Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe biggest challenge in endoscopic surveillance of Barrett's oesophagus is better detection of neoplasia in mucosa of normal macroscopic appearance. We evaluated in vivo miniprobe confocal laser microscopy (CLM) for the detection of invisible Barrett's neoplasia.
designProspective two-centre trial in two phases: phase I to establish criteria of Barrett's neoplasia and phase II to test these criteria. PATIENTS AND
intervention296 biopsy sites in 38 consecutive patients with Barrett's oesophagus (mean age 62.1 years, 89.5% men, median length of the Barrett's oesophagus, 3 cm) were examined with standard high-resolution endoscopy and by miniprobe CLM, with precise matching of CLM recordings to biopsy sites. CLM image criteria for normal versus neoplastic Barrett's oesophagus were established from 95 biopsies of 15 patients (phase I); these criteria were then prospectively tested on 201 biopsies from the remaining patients without visible focal changes (phase II). All 201 CLM video recordings from phase II cases were randomised and blindly evaluated by two gastroenterologists.
main outcome measureThe primary endpoints were accuracy values in diagnosing HGIN or early carcinoma (EC) on a per-biopsy basis. Secondary endpoints included inter-observer agreement.
resultsAll initially defined miniprobe CLM criteria (phase I) were significantly more frequently detected in HGIN/EC sites compared with sites with no or low grade neoplasia (phase II). In a per-biopsy analysis, sensitivity and specificity for two independent investigators were 75.0% and 88.8%, and 75.0% and 91.0%, respectively, translating at best into a positive predictive value of 44.4% and a negative predictive value of 98.8%. Inter-observer agreement was good (kappa 0.6).
conclusionMiniprobe CLM showed a high negative predictive value for the diagnosis of endoscopically invisible neoplasia in Barrett's oesophagus; sensitivity, however, has still to be improved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.