ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2008
Somatostatin stimulates menin gene expression by inhibiting protein kinase A.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- A neural substrate of comorbid depressive symptoms in alcohol use.Molecular psychiatry · 2025Article
- Hypothalamic Menin regulates systemic aging and cognitive decline.PLoS biology · 2023Article
- [Morphological characteristics of pituitary adenomas in the phenocopy of multiple endocrine neoplasia type 1].Problemy endokrinologii · 2021Article
- Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells.Gastroenterology · 2017Article
- Epigenetic regulation by the menin pathway.Endocrine-related cancer · 2017Review
- Deletion ofGut · 2017Article
- Modulation by miR-29b of intestinal epithelium homoeostasis through the repression of menin translation.The Biochemical journal · 2015Article
- Menin: a scaffold protein that controls gene expression and cell signaling.Trends in biochemical sciences · 2013Review
- Menin and GIP are inversely regulated by food intake and diet via PI3/AKT signaling in the proximal duodenum.Nutrition & diabetes · 2012Article
- Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- A high-fat diet regulates gastrin and acid secretion through primary cilia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Expression and subcellular localization of menin in human cancer cells.Experimental and therapeutic medicine · 2012Article
- Menin and JunD regulate gastrin gene expression through proximal DNA elements.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Gastric tuft cells express DCLK1 and are expanded in hyperplasia.Histochemistry and cell biology · 2011Article
- Menin immunoreactivity in secretory granules of human pancreatic islet cells.Applied immunohistochemistry & molecular morphology : AIMMArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Somatostatin is a potent inhibitor of gastrin secretion and gene expression. Menin is a 67-kDa protein product of the multiple endocrine neoplasia type 1 (MEN1) gene that when mutated leads to duodenal gastrinomas, a tumor that overproduces the hormone gastrin. These observations suggest that menin might normally inhibit gastrin gene expression in its role as a tumor suppressor. Since somatostatin and ostensibly menin are both inhibitors of gastrin, we hypothesized that somatostatin signaling directly induces menin. Menin protein expression was significantly lower in somatostatin-null mice, which are hypergastrinemic. We found by immunohistochemistry that somatostatin receptor-positive cells (SSTR2A) express menin. Mice were treated with the somatostatin analog octreotide to determine whether activation of somatostatin signaling induced menin. We found that octreotide increased the number of menin-expressing cells, menin mRNA, and menin protein expression. Moreover, the induction by octreotide was greater in the duodenum than in the antrum. The increase in menin observed in vivo was recapitulated by treating AGS and STC cell lines with octreotide, demonstrating that the regulation was direct. The induction required suppression of protein kinase A (PKA) since forskolin treatment suppressed menin protein levels and octreotide inhibited PKA enzyme activity. Small-interfering RNA-mediated suppression of PKA levels raised basal levels of menin protein and prevented further induction by octreotide. Using AGS cells, we also showed for the first time that menin directly inhibits endogenous gastrin gene expression. In conclusion, somatostatin receptor activation induces menin expression by suppressing PKA activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.