ArticleThe Journal of physiology2008
Epileptiform activities in slices of hippocampus from mice after intra-hippocampal injection of kainic acid.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Wnt activation during epileptogenesis prevents pathological immature dentate granule cell morphological changes in animal models of unilateral and bilateral temporal lobe epilepsy.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026Article
- Increased Dentate Gyrus Excitability in the Intrahippocampal Kainic Acid Mouse Model for Temporal Lobe Epilepsy.International journal of molecular sciences · 2024Article
- Intracranial electrophysiological recordings on a swine model of mesial temporal lobe epilepsy.Frontiers in neurology · 2023Article
- Reactive morphology of dividing microglia following kainic acid administration.Frontiers in neuroscience · 2022Article
- Intrinsic Inflammation Is a Potential Anti-Epileptogenic Target in the Organotypic Hippocampal Slice Model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Article
- Position- and Time-DependentFrontiers in cellular neuroscience · 2018Article
- Brain extracellular space, hyaluronan, and the prevention of epileptic seizures.Reviews in the neurosciences · 2017Review
- Disrupted Co-activation of Interneurons and Hippocampal Network after Focal Kainate Lesion.Frontiers in neural circuits · 2017Article
- Article
- Homeostasis or channelopathy? Acquired cell type-specific ion channel changes in temporal lobe epilepsy and their antiepileptic potential.Frontiers in physiology · 2015Review
- Progressive, potassium-sensitive epileptiform activity in hippocampal area CA3 of pilocarpine-treated rats with recurrent seizures.Epilepsy research · 2011Article
- Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- 'Leaky' neurons in the epileptic hippocampus: should we get excited?The Journal of physiology · 2009Article
- Upregulation of inward rectifier K+ (Kir2) channels in dentate gyrus granule cells in temporal lobe epilepsy.The Journal of physiology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Intra-hippocampal kainate injection induces the emergence of recurrent seizures after a delay of 3-4 weeks. We examined the cellular and synaptic basis of this activity in vitro using extracellular and intracellular records from longitudinal hippocampal slices. These slices permitted recordings from the dentate gyrus, the CA3 and CA1 regions and the subiculum of both the injected and the contralateral non-injected hippocampus. A sclerotic zone was evident in dorsal regions of slices from the injected hippocampus, while ventral regions and tissue from the contralateral hippocampus were not sclerotic. Interictal field potentials of duration 50-200 ms were generated spontaneously in both ipsilateral and contralateral hippocampal slices, but not in the sclerotic region, at 3-12 months after injection. They were initiated in the CA1 and CA3 regions and the subiculum. They were blocked by antagonists at glutamatergic receptors and were transformed into prolonged epileptiform events by GABAergic receptor antagonists. The membrane potential and the reversal potential of GABAergic synaptic events were more depolarized in CA1 pyramidal cells from kainate-treated animals than in control animals. Ictal-like events of duration 8-80 s were induced by tetanic stimulation (50 Hz, 0.2-1 s) preferentially in dorsal contralateral and ventral ipsilateral slices. Similar events were initiated by focal application of a combination of high K(+) and GABA. These data show that both interictal and ictal-like activities can be induced in slices of both ipsilateral and contralateral hippocampus from kainate-treated animals and suggest that changes in cellular excitability and inhibitory synaptic signalling may contribute to their generation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.