ArticleThe Journal of antimicrobial chemotherapy2008
Vibrio cholerae O1 from Accra, Ghana carrying a class 2 integron and the SXT element.
Article in The Journal of antimicrobial chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Cholera burden in Ghana: a systematic review and meta-analysis of prevalence, antimicrobial resistance and risk factors.International health · 2025Pooled it
- Antibiotic-Resistant Vibrio cholerae O1 and Its SXT Elements Associated with Two Cholera Epidemics in Kenya in 2007 to 2010 and 2015 to 2016.Microbiology spectrum · 2023Article
- A bottom-up view of antimicrobial resistance transmission in developing countries.Nature microbiology · 2022Review
- In Silico Detection of Antimicrobial Resistance Integrons inAntibiotics (Basel, Switzerland) · 2021Article
- Phylogenetic and antimicrobial drug resistance analysis ofMicrobial genomics · 2021Article
- Antibiotic resistance patterns in human, animal, food and environmental isolates in Ghana: a review.The Pan African medical journal · 2020Review
- Review of molecular subtyping methodologies used to investigate outbreaks due to multidrug-resistant enteric bacterial pathogens in sub-Saharan Africa.African journal of laboratory medicine · 2019Review
- Environmental surveillance for Vibrio cholerae in selected households' water storage systems in Accra Metropolitan Area (AMA) prior to the 2014 cholera outbreak in Accra, Ghana.Environmental science and pollution research international · 2018Article
- Antimicrobial resistance ofAfrican journal of laboratory medicine · 2018Review
- Vibrio Pathogens: A Public Health Concern in Rural Water Resources in Sub-Saharan Africa.International journal of environmental research and public health · 2017Review
- Identification of AtypicalFrontiers in microbiology · 2017Article
- Laboratory systems as an antibacterial resistance containment tool in Africa.African journal of laboratory medicine · 2016Review
- Surveillance of Bacterial Pathogens of Diarrhoea in Two Selected Sub Metros Within the Accra Metropolis.Ghana medical journal · 2015Article
- Article
- Worldwide occurrence of integrative conjugative element encoding multidrug resistance determinants in epidemic Vibrio cholerae O1.PloS one · 2014Article
- Cholera outbreaks in Nigeria are associated with multidrug resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae.PLoS neglected tropical diseases · 2013Article
- Regional dissemination of a trimethoprim-resistance gene cassette via a successful transposable element.PloS one · 2012Article
- Rapid evolution of fluoroquinolone-resistant Escherichia coli in Nigeria is temporally associated with fluoroquinolone use.BMC infectious diseases · 2011Article
- Genetic characterization of multidrug-resistant, extended-spectrum- β-lactamase-producing Vibrio cholerae O1 outbreak strains, Mpumalanga, South Africa, 2008.Journal of clinical microbiology · 2011Article
- Quinolone resistance in Escherichia coli from Accra, Ghana.BMC microbiology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesVibrio cholerae O1 from a 2006 outbreak in Accra were commonly resistant to multiple antimicrobials and, in particular, to trimethoprim/sulfamethoxazole, drugs commonly used in the treatment of cholera. We sought to determine the genetic basis for trimethoprim/sulfamethoxazole resistance in outbreak isolates.
methodsTwenty-seven isolates from the outbreak were screened by PCR and sequencing for class 1 and 2 integrons and for the SXT element.
resultsTwenty-one of the 27 isolates examined, all from the Accra metropolitan area, carried both SXT, an integrated chromosomal element, and a class 2 integron bearing dfrA1, sat and aadA1 cassettes. All these isolates had identical random amplification of polymorphic DNA profiles and two of them also carried a class 1 integron.
conclusionsMost strains characterized carried multiple elements conferring resistance to trimethoprim. This suggests that trimethoprim/sulfamethoxazole should not be used empirically in cholera treatment.
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