Evidence map›Paper›PMID 18755385›Full record

ReviewInfectious disease clinics of North America2008

Human babesiosis.

Edouard Vannier, Benjamin E Gewurz, Peter J Krause

Abstract readReview
In one paragraph

Review in Infectious disease clinics of North America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 4 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 4 syntheses or guidelines pooled it, 254 citations in OpenAlex.

  1. Mapping the Global Distribution ofTransboundary and emerging diseases · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Article
  9. Evaluating acridones as novel therapeutics for human babesiosis.Antimicrobial agents and chemotherapy · 2026
    Article
  10. Article
  11. Babesiosis and Its Significance in Transfusion Medicine from a European Point of View.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026
    Review
  12. Urban surveillance ofFrontiers in veterinary science · 2026
    Article
  13. Article
  14. Long-term survival ofMicrobiology spectrum · 2025
    Article
  15. Review
  16. Molecular survey of tick-borne pathogens in domestic dogs from a rural region within the buffer zone of a conservation unit in the Brazilian Caatinga biome.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2025
    Article
  17. A set of diagnostic tests for detection of active Babesia duncani infection.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024
    Article
  18. Article
  19. Comparative chemical genomics inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Review

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Edouard VannierDivision of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Boston, MA 02111, USA.
Benjamin E Gewurz
Peter J Krause
Connecticut Children's Medical Center · USHarvard University · USTufts University · US

Funding

ZONISAMIDE VERSUS PLACEBOM01RR006192 · NCRR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KRANZLER, HENRY RICHARD · 1994 to 2008
$22.1M
Babesiosis as a Model of Age-Related ImmunosenescenceR01AG019781 · NIA · TUFTS UNIVERSITY BOSTON · PI VANNIER, EDOUARD G, WORTIS, HENRY H. · 2002 to 2012
$4.7M
NCRR NIH HHS M01 RR006192NCRR NIH HHS RR06192NIA NIH HHS AG19781NIA NIH HHS R01 AG019781
6 · The paper itself

Abstract

Human babesiosis is an emerging intraerythrocytic infection caused by protozoal parasites transmitted by ixodid ticks. Babesiosis is endemic in the northeastern and upper midwestern regions of the United States and is found sporadically in other parts of the United States, Europe, Asia, Africa, and South America. Babesial infections range from asymptomatic to severe and occasionally are fatal. Specific laboratory diagnosis of babesial infection is made by morphologic examination of Giemsa-stained blood smears, serology, and amplification of babesial DNA using polymerase chain reaction. The combination of atovaquone and azithromycin is the treatment of choice for mild-to-moderate illness, whereas clindamycin and quinine and exchange transfusion are indicated for severe disease.

Indexed as

AnimalsAntiprotozoal AgentsArachnid VectorsBabesiaBabesiosisDiagnosis, DifferentialDNA, ProtozoanHumansIxodidaePolymerase Chain ReactionSeverity of Illness IndexUnited StatesZoonosesAntiprotozoal AgentsDNA, Protozoan

Identifiers

PMID18755385
PMCPMC3998201
OpenAlexW4211001296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.