ArticleBritish journal of clinical pharmacology2008
Uncovering the potential risk of serotonin toxicity in Australian veterans using pharmaceutical claims data.
Article in British journal of clinical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Review
- Combating escalating harms associated with pharmaceutical opioid use in Australia: the POPPY II study protocol.BMJ open · 2018Article
- Tramadol Pill Alone May Cause Serotonin Syndrome.Chinese medical journal · 2016Article
- The POPPY Research Programme protocol: investigating opioid utilisation, costs and patterns of extramedical use in Australia.BMJ open · 2015Article
- The use and impact of cancer medicines in routine clinical care: methods and observations in a cohort of elderly Australians.BMJ open · 2014Article
- Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans.The pharmacogenomics journal · 2013Article
- Deaths involving contraindicated and inappropriate combinations of serotonergic drugs.International journal of legal medicine · 2011Article
- Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment.British journal of clinical pharmacology · 2011Review
- Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice.The international journal of neuropsychopharmacology · 2009Article
- Methods in clinical pharmacology--a tale of two worlds.British journal of clinical pharmacology · 2008Article
- Assessment and management of serotonin syndrome in a simulated patient study of Australian community pharmacies.Pharmacy practiceArticle
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWe examined potential risk of serotonin toxicity in Australian veterans by quantifying the concomitant use of serotonergic medicine combinations from claims data collected by the Department of Veterans' Affairs (DVA).
methodsThis was a retrospective cohort study of 273 228 Australian veterans, war widows, widowers and dependents aged >or=55 years and holding full treatment entitlement for the period July 2000 to June 2004 or until death. The main outcome measure was potential concomitant use, estimated as the number of cohort members with an overlap in days of supply for serotonergic medicine combinations over the 4 year period for all medicine combinations and potentially life threatening combinations.
resultsFrom July 2000 to June 2004, 115 969 (42%) cohort members were dispensed at least one serotonergic medicine. 20 658 (8%) had at least one episode of potential concomitant use. We identified 1811 (0.7%) cohort members with at least one overlapping period of potentially life-threatening serotonergic medicine combinations, 937 of whom had the combinations dispensed within the recommended washout period. Three hundred and seventeen of these individuals were dispensed potentially life-threatening medicine combinations on the same day. The most common combinations were moclobemide with a selective serotonin reuptake inhibitor or tramadol.
conclusionsThe individuals potentially at risk of mild to moderate serotonin toxicity were considerable and potentially life threatening combinations were not infrequent. While we were unable to determine how many individuals experienced serotonin toxicity this study indicates, for the first time, the potential size of the problem in a subgroup of elderly Australians. Clinicians and patients need to be vigilant regarding inadvertent concomitant use, especially that of moclobemide with a selective serotonin reuptake inhibitor or tramadol.
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