ArticleNano letters2008
Nanoparticles for gene transfer to human embryonic stem cell colonies.
Article in Nano letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 107 citations in OpenAlex.
- Nanotechnology to Overcome Blood-Brain Barrier Permeability and Damage in Neurodegenerative Diseases.Pharmaceutics · 2025Review
- Cell-drug conjugates.Nature biomedical engineering · 2024Review
- Synthesis and Mass Spectrometry Structural Assessment of Polyesteramides Based on ε-Caprolactone and L-Phenylalanine.Polymers · 2024Article
- Enhancing Stem Cell-Based Therapeutic Potential by Combining Various Bioengineering Technologies.Frontiers in cell and developmental biology · 2022Review
- Potential and Applications of Nanocarriers for Efficient Delivery of Biopharmaceuticals.Pharmaceutics · 2020Review
- Oligopeptide-modified poly(beta-amino ester)s-coated AdNuPARmE1A: Boosting the efficacy of intravenously administered therapeutic adenoviruses.Theranostics · 2020Article
- A combinatorial library of biodegradable polyesters enables non-viral gene delivery to post-mitotic human stem cell-derived polarized RPE monolayers.Regenerative engineering and translational medicine · 2019Article
- Efficient delivery of C/EBP beta gene into human mesenchymal stem cells via polyethylenimine-coated gold nanoparticles enhances adipogenic differentiation.Scientific reports · 2016Article
- High content analysis platform for optimization of lipid mediated CRISPR-Cas9 delivery strategies in human cells.Acta biomaterialia · 2016Article
- Niemann-Pick C1 affects the gene delivery efficacy of degradable polymeric nanoparticles.ACS nano · 2014Article
- Cationic, helical polypeptide-based gene delivery for IMR-90 fibroblasts and human embryonic stem cells.Biomaterials science · 2013Article
- Embryonic and induced pluripotent stem cells: understanding, creating, and exploiting the nano-niche for regenerative medicine.ACS nano · 2013Review
- Physical non-viral gene delivery methods for tissue engineering.Annals of biomedical engineering · 2013Review
- Nanotopography-mediated reverse uptake for siRNA delivery into neural stem cells to enhance neuronal differentiation.Scientific reports · 2013Article
- Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation.Biomaterials · 2012Article
- 2011 Rita Schaffer lecture: nanoparticles for intracellular nucleic acid delivery.Annals of biomedical engineering · 2012Article
- Therapeutic angiogenesis using genetically engineered human endothelial cells.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- Reactive and bioactive cationic α-helical polypeptide template for nonviral gene delivery.Angewandte Chemie (International ed. in English) · 2012Article
- Influence of nanomaterials on stem cell differentiation: designing an appropriate nanobiointerface.International journal of nanomedicine · 2012Review
- Discovery of cationic polymers for non-viral gene delivery using combinatorial approaches.Combinatorial chemistry & high throughput screening · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We develop biodegradable polymeric nanoparticles to facilitate nonviral gene transfer to human embryonic stem cells (hESCs). Small (approximately 200 nm), positively charged (approximately 10 mV) particles are formed by the self assembly of cationic, hydrolytically degradable poly(beta-amino esters) and plasmid DNA. By varying the end group of the polymer, we can tune the biophysical properties of the resulting nanoparticles and their gene-delivery efficacy. We created an OCT4-driven GFP hES cell line to allow the rapid identification of nanoparticles that facilitate gene transfer while maintaining an hESC undifferentiated state. Using this cell system, we synthesized nanoparticles that have gene delivery efficacy that is up to 4 times higher than that of the leading commercially available transfection agent, Lipofectamine 2000. Importantly, these materials have minimal toxicity and do not adversely affect hESC colony morphology or cause nonspecific differentiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.