ArticleGenes and immunity2009
Bone marrow cells produce a novel TSHbeta splice variant that is upregulated in the thyroid following systemic virus infection.
Article in Genes and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Extrathyroidal Expression of the Thyrotropin Receptor in Epithelial Cancer Cells.International journal of molecular sciences · 2026Article
- Molecular and Functional Insights into Thyrostimulin and Its Subunits-GPA2/GPB5.International journal of molecular sciences · 2025Review
- Neuroendocrinology of bone.Pituitary · 2024Review
- Pituitary crosstalk with bone, adipose tissue and brain.Nature reviews. Endocrinology · 2023Review
- The interplay of thyroid hormones and the immune system - where we stand and why we need to know about it.European journal of endocrinology · 2022Review
- Thyroid-stimulating hormone decreases the risk of osteoporosis by regulating osteoblast proliferation and differentiation.BMC endocrine disorders · 2021Article
- Unconventional Actions of Glycoprotein Hormone Subunits: A Comprehensive Review.Frontiers in endocrinology · 2021Review
- Dynamic Interactions Between the Immune System and the Neuroendocrine System in Health and Disease.Frontiers in endocrinology · 2021Review
- The Human TSHβ Subunit Proteins and Their Binding Sites on the TSH Receptor Using Molecular Dynamics Simulation.Endocrinology · 2020Article
- Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection.General and comparative endocrinology · 2020Article
- Novel Splicing of Immune System Thyroid Stimulating Hormone β-Subunit-Genetic Regulation and Biological Importance.Frontiers in endocrinology · 2019Review
- Actions of pituitary hormones beyond traditional targets.The Journal of endocrinology · 2018Review
- Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology.Frontiers in endocrinology · 2017Review
- T3 Regulates a Human Macrophage-Derived TSH-β Splice Variant: Implications for Human Bone Biology.Endocrinology · 2016Article
- Role of Thyroid Hormones in Skeletal Development and Bone Maintenance.Endocrine reviews · 2016Review
- Splenic Leukocytes Traffic to the Thyroid and Produce a Novel TSHβ Isoform during Acute Listeria monocytogenes Infection in Mice.PloS one · 2016Article
- Splicing Regulation of Pro-Inflammatory Cytokines and Chemokines: At the Interface of the Neuroendocrine and Immune Systems.Biomolecules · 2015Review
- Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development.Endocrinology · 2015Article
- Oxytocin and bone.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Review
- Biological Impact of the TSHβ Splice Variant in Health and Disease.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Although cells of the immune system can produce thyroid-stimulating hormone (TSH), the significance of that remains unclear. Using 5' rapid amplification of cDNA ends (RACE), we show that mouse bone marrow (BM) cells produce a novel in-frame TSHbeta splice variant generated from a portion of intron 4 with all of the coding region of exon 5, but none of exon 4. The TSHbeta splice variant gene was expressed at low levels in the pituitary, but at high levels in the BM and the thyroid, and the protein was secreted from transfected Chinese hamster ovary (CHO) cells. Immunoprecipitation identified an 8 kDa product in lysates of CHO cells transfected with the novel TSHbeta construct, and a 17 kDa product in lysates of CHO cells transfected with the native TSHbeta construct. The splice variant TSHbeta protein elicited a cAMP response from FRTL-5 thyroid follicular cells and a mouse alveolar macrophage (AM) cell line. Expression of the TSHbeta splice variant, but not the native form of TSHbeta, was significantly upregulated in the thyroid during systemic virus infection. These studies characterize the first functional splice variant of TSHbeta, which may contribute to the metabolic regulation during immunological stress, and may offer a new perspective for understanding autoimmune thyroiditis.
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Registered trials
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