ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
TARP redundancy is critical for maintaining AMPA receptor function.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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Who cites it
44 citing papers in PubMed, 73 citations in OpenAlex.
- Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum.Science (New York, N.Y.) · 2026Article
- Sex differences in AMPA receptor trafficking proteins.Biology of sex differences · 2026Review
- Knockout of AMPA receptor binding protein Neuron-specific gene 2 (NSG2) enhances associative learning and cognitive flexibility.Molecular brain · 2024Article
- Knockout of AMPA receptor binding protein Neuron-Specific Gene 2 (NSG2) enhances associative learning and cognitive flexibility.Research square · 2024Article
- Glutamate Receptors and C-ABL Inhibitors: A New Therapeutic Approach for Parkinson's Disease.Central nervous system agents in medicinal chemistry · 2024Review
- Article
- Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex.Cell reports · 2022Article
- Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability.Molecular psychiatry · 2022Article
- AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs.Neuropharmacology · 2021Review
- Calcineurin Participation in Hebbian and Homeostatic Plasticity Associated With Extinction.Frontiers in cellular neuroscience · 2021Review
- Review
- AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking.Cellular and molecular life sciences : CMLS · 2019Review
- The AMPA Receptor Code of Synaptic Plasticity.Neuron · 2018Review
- Cerebellar synapse properties and cerebellum-dependent motor and non-motor performance inDisease models & mechanisms · 2018Article
- LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- TARP γ-2 Is Required for Inflammation-Associated AMPA Receptor Plasticity within Lamina II of the Spinal Cord Dorsal Horn.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- TARP γ-2 and γ-8 Differentially Control AMPAR Density Across Schaffer Collateral/Commissural Synapses in the Hippocampal CA1 Area.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Synaptic localization of neurotransmitter receptors: comparing mechanisms for AMPA and GABAA receptors.Current opinion in pharmacology · 2015Review
- Stargazin promotes closure of the AMPA receptor ligand-binding domain.The Journal of general physiology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Transmembrane AMPA receptor regulatory proteins (TARPs) are AMPA receptor auxiliary subunits that influence diverse aspects of receptor function. However, the full complement of physiological roles for TARPs in vivo remains poorly understood. Here we find that double knock-out mice lacking TARPs gamma-2 and gamma-3 are profoundly ataxic and fail to thrive. We demonstrate that these TARPs are critical for the synaptic targeting and kinetics of AMPA receptors in cerebellar Golgi cells, but that either alone is sufficient to fully preserve function. By analyzing the few remaining synaptic AMPA receptors in the gamma-2, gamma-3 double knock-out mice, we unexpectedly find that these TARPs specify AMPA receptor subunit composition. This study establishes a new role for TARPs in regulating AMPA receptor assembly and suggests that TARPs are necessary for proper AMPA receptor localization and function in most, if not all, neurons of the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.