ArticleJournal of clinical microbiology2008
Urinary tract infections in a South American population: dynamic spread of class 1 integrons and multidrug resistance by homologous and site-specific recombination.
Article in Journal of clinical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Frequency of Antimicrobial Resistance Among Fecal Bacteria Pathogens in an Informal Settlement in Nairobi, Kenya, 2018 to 2020.Microorganisms · 2026Article
- Genetics of resistance to trimethoprim in cotrimoxazole resistant uropathogenicFrontiers in microbiology · 2024Article
- Impacts of Domestication and Veterinary Treatment on Mobile Genetic Elements and Resistance Genes in Equine Fecal Bacteria.Applied and environmental microbiology · 2023Article
- Whole-genome sequence analysis of environmentalMicrobial genomics · 2020Article
- Predictors of Urinary Tract Infections in Children and Antibiotic Susceptibility Pattern in the Buea Health District, South West Region, Cameroon.BioMed research international · 2020Article
- Article
- Antibiotic resistance profiling of pathogenic Enterobacteriaceae from Cluj-Napoca, Romania.Germs · 2019Article
- Whole genome sequence analysis of Australian avian pathogenic Escherichia coli that carry the class 1 integrase gene.Microbial genomics · 2019Article
- Genomic Epidemiology of NDM-1-Encoding Plasmids in Latin American Clinical Isolates Reveals Insights into the Evolution of Multidrug Resistance.Genome biology and evolution · 2017Article
- Exploring the Role of Coliform Bacteria in Class 1 Integron Carriage and Biofilm Formation During Drinking Water Treatment.Microbial ecology · 2016Article
- Characterization of a Novel IncHI2 Plasmid Carrying Tandem Copies of blaCTX-M-2 in a fosA6-Harboring Escherichia coli Sequence Type 410 Strain.Antimicrobial agents and chemotherapy · 2016Article
- Multidrug- and Extensively Drug-Resistant UropathogenicFrontiers in microbiology · 2016Article
- Resistant plasmid profile analysis of multidrug resistant Escherichia coli isolated from urinary tract infections in Abeokuta, Nigeria.African health sciences · 2014Article
- Clonal composition and community clustering of drug-susceptible and -resistant Escherichia coli isolates from bloodstream infections.Antimicrobial agents and chemotherapy · 2013Article
- Globally dispersed mobile drug-resistance genes in gram-negative bacterial isolates from patients with bloodstream infections in a US urban general hospital.Journal of medical microbiology · 2012Article
- Article
- Genetic context and structural diversity of class 1 integrons from human commensal bacteria in a hospital intensive care unit.Antimicrobial agents and chemotherapy · 2011Article
- Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: a comparative study.Antimicrobial agents and chemotherapy · 2011Article
- Atypical class 1 integron coexists with class 1 and class 2 integrons in multi-drug resistant Shigella flexneri isolates from China.Current microbiology · 2011Article
- Sequence of pR3521, an IncB plasmid from Escherichia coli encoding ACC-4, SCO-1, and TEM-1 beta-lactamases.Antimicrobial agents and chemotherapy · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One hundred four bacterial strains mediating urinary tract infections in separate individuals from a Uruguayan community were isolated. Forty-six strains conferred a multidrug resistance phenotype. All 104 strains were examined for the presence of class 1, 2, and 3 integrons. Class 1 integrons were found in 21 isolates across four distinct bacterial genera. A large class 1 integron in a Klebsiella pneumoniae strain was fully sequenced and was 29,093 bp in length. This integron probably arose by homologous recombination since it was embedded in a hybrid Tn21-like transposon backbone which comprised a Tn5036-like tnp transposition module at the IRi integron end and a Tn21 mer module at the IRt integron end. The parent integron/transposon that contributed the Tn5036 module was not related to Tn1696 since the integron insertion points in the transposon backbones were 16 bases apart. Examination of the other 20 class 1 integron-containing strains revealed further evidence of genetic exchange. This included a strain that possessed a Tn5036 module at the IRt end but not at the IRi end and another that possessed a tnp module beyond IRi that was a hybrid of Tn21 and Tn5051 and that is presumed to have arisen by site-specific recombination. This study highlights the ability of different genetic elements to act cooperatively to spread and rearrange antibiotic resistance in a community.
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