ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
Identification of cold-shock protein RBM3 as a possible regulator of skeletal muscle size through expression profiling.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- RNA-Binding Motif Protein 3 as a Therapeutic and Prognostic Target for Drug Discovery.Current issues in molecular biology · 2026Review
- Proteomic Analysis of the Periodontal Ligament During Orthodontic Movement: A Study in Rats.Proteomes · 2025Article
- Molecular regulation of reversible cardiac remodeling: lessons from species with extreme physiological adaptations.The Journal of experimental biology · 2024Review
- Article
- The transcript interactome of skeletal muscle RNA binding protein motif 3 (RBM3).Physiological reports · 2023Article
- RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure.Cell stress & chaperones · 2022Article
- Angiostatic freeze or angiogenic move? Acute cold stress prevents angiokine secretion from murine myotubes but primes primary endothelial cells for greater migratory capacity.Frontiers in physiology · 2022Article
- Skeletal muscle RBM3 expression is associated with extended lifespan in Ames Dwarf and calorie restricted mice.Experimental gerontology · 2021Article
- Age-related responses to a bout of mechanotherapy in skeletal muscle of rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Skeletal muscle cold shock and heat shock protein mRNA response to aerobic exercise in different environmental temperatures.Temperature (Austin, Tex.) · 2019Article
- Morphoregulatory functions of the RNA-binding motif protein 3 in cell spreading, polarity and migration.Scientific reports · 2018Article
- Cold shock protein RBM3 attenuates atrophy and induces hypertrophy in skeletal muscle.Journal of muscle research and cell motility · 2018Article
- Local cryotherapy minimally impacts the metabolome and transcriptome of human skeletal muscle.Scientific reports · 2017Article
- RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection.Oncotarget · 2017Review
- Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold.Cellular and molecular life sciences : CMLS · 2016Review
- Relative extended haplotype homozygosity signals across breeds reveal dairy and beef specific signatures of selection.Genetics, selection, evolution : GSE · 2015Article
- Regrowth after skeletal muscle atrophy is impaired in aged rats, despite similar responses in signaling pathways.Experimental gerontology · 2015Article
- Pharmacology of manipulating lean body mass.Clinical and experimental pharmacology & physiology · 2015Review
- The role of microRNAs in skeletal muscle health and disease.Frontiers in bioscience (Landmark edition) · 2015Review
- Comparative functional genomics of adaptation to muscular disuse in hibernating mammals.Molecular ecology · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Changes in gene expression associated with skeletal muscle atrophy due to aging are distinct from those due to disuse, suggesting that the response of old muscle to inactivity may be altered. The goal of this study was to identify changes in muscle gene expression that may contribute to loss of adaptability of old muscle. Muscle atrophy was induced in young adult (6-mo) and old (32-mo) male Brown Norway/F344 rats by 2 wk of hindlimb suspension (HS), and soleus muscles were analyzed by cDNA microarrays. Overall, similar changes in gene expression with HS were observed in young and old muscles for genes encoding proteins involved in protein folding (heat shock proteins), muscle structure, and contraction, extracellular matrix, and nucleic acid binding. More genes encoding transport and receptor proteins were differentially expressed in the soleus muscle from young rats, while in soleus muscle from old rats more genes that encoded ribosomal proteins were upregulated. The gene encoding the cold-shock protein RNA-binding motif protein-3 (RBM3) was induced most highly with HS in muscle from old rats, verified by real-time RT-PCR, while no difference with age was observed. The cold-inducible RNA-binding protein (Cirp) gene was also overexpressed with HS, whereas cold-shock protein Y-box-binding protein-1 was not. A time course analysis of RBM3 mRNA abundance during HS showed that upregulation occurred after apoptotic nuclei and markers of protein degradation increased. We conclude that a cold-shock response may be part of a compensatory mechanism in muscles undergoing atrophy to preserve remaining muscle mass and that RBM3 may be a therapeutic target to prevent muscle loss.
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