ArticleThe Journal of general virology2008
The dual role of dendritic cells in the immune response to human immunodeficiency virus type 1 infection.
Article in The Journal of general virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Three-stage modeling of HIV infection and implications for antiretroviral therapy.Journal of mathematical biology · 2024Article
- Article
- Modeling the immune response to HIV infection.Current opinion in systems biology · 2018Article
- Modeling Kick-Kill Strategies toward HIV Cure.Frontiers in immunology · 2017Review
- Dynamics of HIV infection in lymphoid tissue network.Journal of mathematical biology · 2016Article
- Tropism of CPMV to Professional Antigen Presenting Cells Enables a Platform to Eliminate Chronic Infections.ACS biomaterials science & engineering · 2015Article
- Effects of neutralizing antibodies on escape from CD8+ T-cell responses in HIV-1 infection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Computational study to determine when to initiate and alternate therapy in HIV infection.BioMed research international · 2014Article
- Review
- Review
- Host immune responses that promote initial HIV spread.Journal of theoretical biology · 2011Article
- A hybrid multi-compartment model of granuloma formation and T cell priming in tuberculosis.Journal of theoretical biology · 2011Article
- Innate immune activation in primary HIV-1 infection.The Journal of infectious diseases · 2010Review
- Model of colonic inflammation: immune modulatory mechanisms in inflammatory bowel disease.Journal of theoretical biology · 2010Article
- HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?PLoS pathogens · 2010Review
- Utilizing the FIV model to understand dendritic cell dysfunction and the potential role of dendritic cell immunization in HIV infection.Veterinary immunology and immunopathology · 2010Review
- A multifaceted approach to modeling the immune response in tuberculosis.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Many aspects of the complex interaction between human immunodeficiency virus type 1 (HIV-1) and the human immune system remain elusive. Our objective was to study these interactions, focusing on the specific roles of dendritic cells (DCs). DCs enhance HIV-1 infection processes as well as promote an antiviral immune response. We explored the implications of these dual roles. A mathematical model describing the dynamics of HIV-1, CD4+ and CD8+ T-cells, and DCs interacting in a human lymph node was analysed and is presented here. We have validated the behaviour of our model against non-human primate simian immunodeficiency virus experimental data and published human HIV-1 data. Our model qualitatively and quantitatively recapitulates clinical HIV-1 infection dynamics. We have performed sensitivity analyses on the model to determine which mechanisms strongly affect infection dynamics. Sensitivity analysis identifies system interactions that contribute to infection progression, including DC-related mechanisms. We have compared DC-dependent and -independent routes of CD4+ T-cell infection. The model predicted that simultaneous priming and infection of T cells by DCs drives early infection dynamics when activated T-helper cell numbers are low. Further, our model predicted that, while direct failure of DC function and an indirect failure due to loss of CD4+ T-helper cells are both significant contributors to infection dynamics, the former has a more significant impact on HIV-1 immunopathogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.