ArticleJournal of cellular and molecular medicine2009
Simple application of fibronectin-mimetic coating enhances osseointegration of titanium implants.
Article in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 85 citations in OpenAlex.
- Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Molecular dynamics simulation in tissue engineering.BioImpacts : BI · 2025Review
- Biomimetic optimization of silicone breast implant integration: insights into wound healing and the foreign body response.Frontiers in bioengineering and biotechnology · 2025Review
- CHARMM-GUI Nanomaterial Modeler for Modeling and Simulation of Nanomaterial Systems.Journal of chemical theory and computation · 2022Article
- Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration.Frontiers in bioengineering and biotechnology · 2022Article
- A biomimetic engineered bone platform for advanced testing of prosthetic implants.Scientific reports · 2020Article
- The Body's Cellular and Molecular Response to Protein-Coated Medical Device Implants: A Review Focused on Fibronectin and BMP Proteins.International journal of molecular sciences · 2020Review
- Commentary: A Cost-Effective Method to Enhance Adenoviral Transduction of Primary Murine Osteoblasts and Bone Marrow Stromal Cells.Frontiers in endocrinology · 2020Article
- Micro/Nano Structural Tantalum Coating for Enhanced Osteogenic Differentiation of Human Bone Marrow Stem Cells.Materials (Basel, Switzerland) · 2018Article
- Biomimetic Implant Surface Functionalization with Liquid L-PRF Products: In Vitro Study.BioMed research international · 2018Article
- Protein Adsorption to Titanium and Zirconia Using a Quartz Crystal Microbalance Method.BioMed research international · 2017Article
- Sandblasting and fibronectin-derived peptide immobilization on titanium surface increase adhesion and differentiation of osteoblast-like cells (MC3T3-E1).Journal of dental sciences · 2016Article
- Focused Screening of ECM-Selective Adhesion Peptides on Cellulose-Bound Peptide Microarrays.Bioengineering (Basel, Switzerland) · 2016Article
- Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair.Advanced drug delivery reviews · 2015Review
- Simple coating with fibronectin fragment enhances stainless steel screw osseointegration in healthy and osteoporotic rats.Biomaterials · 2015Article
- Advances in surfaces and osseointegration in implantology. Biomimetic surfaces.Medicina oral, patologia oral y cirugia bucal · 2015Review
- Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler.Journal of materials science. Materials in medicine · 2015Article
- Biofunctionalization strategies on tantalum-based materials for osseointegrative applications.Journal of materials science. Materials in medicine · 2015Article
- Implant osseointegration and the role of microroughness and nanostructures: lessons for spine implants.Acta biomaterialia · 2014Review
- Functional tooth regenerative therapy: tooth tissue regeneration and whole-tooth replacement.Odontology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Integrin-mediated cell adhesion to biomolecules adsorbed onto biomedical devices regulates device integration and performance. Because of the central role of integrin-fibronectin (FN) interactions in osteoblastic function and bone formation, we evaluated the ability of FN-inspired biomolecular coatings to promote osteoblastic differentiation and implant osseointegration. Notably, these biomolecular coatings relied on physical adsorption of FN-based ligands onto biomedical-grade titanium as a simple, clinically translatable strategy to functionalize medical implants. Surfaces coated with a recombinant fragment of FN spanning the central cell binding domain enhanced osteoblastic differentiation and mineralization in bone marrow stromal cell cultures and increased implant osseointegration in a rat cortical bone model compared to passively adsorbed arginine-glycine-aspartic acid peptides, serum proteins and full-length FN. Differences in biological responses correlated with integrin binding specificity and signalling among surface coatings. This work validates a simple, clinically translatable, surface biofunctionalization strategy to enhance biomedical device integration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.