ArticleGenetic testing2008
Colorectal cancer cases and relatives of cases indicate similar willingness to receive and disclose genetic information.
Article in Genetic testing, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Universal screening of colorectal tumors for lynch syndrome: a survey of patient experiences and opinions.Hereditary cancer in clinical practice · 2024Article
- Attitudes Toward Glaucoma Genetic Risk Assessment in Unaffected Individuals.Translational vision science & technology · 2022Article
- How do researchers manage genetic results in practice? The experience of the multinational Colon Cancer Family Registry.Journal of community genetics · 2014Article
- Impact of genetic risk assessment on nutrition-related lifestyle behaviours.The Proceedings of the Nutrition Society · 2013Review
- Preferences regarding genetic research results: comparing veterans and nonveterans responses.Public health genomics · 2010Article
- Genetics, genomics, and cancer risk assessment: State of the Art and Future Directions in the Era of Personalized Medicine.CA: a cancer journal for cliniciansReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
contextRecent developments in genetic testing allow us to detect individuals with inherited susceptibility to some cancers. Genetic testing to identify carriers of cancer-related mutations may help lower risk by encouraging preventive behaviors and surveillance. This study assessed willingness of colon cancer cases and relatives to receive genetic information that may indicate an increased risk for cancer, to whom they would disclose genetic information, and whether receiving genetic test results may influence future prevention behaviors among individuals enrolled in the Seattle Colorectal Cancer Family Registry.
methodsIncident invasive colorectal cancer cases were identified from the Puget Sound Surveillance Epidemiology and End Results (SEER) registry. In 2007, a sequential sample of cases and relatives (n = 147) were asked to respond to a questionnaire addressing study aims. The questionnaire was administered during a baseline or 5-year follow-up interview.
resultsPatterns of response to each statement were similar between colorectal cancer cases and relatives. Both colorectal cases (95%) and relatives (95%) reported willingness to receive genetic information. Nearly all participants would tell their doctor the results of a genetic test (99% of cases; 98% of relatives), and all married participants would tell their spouses. Cases (96%) anticipated being slightly more likely than relatives (90%) to change their cancer screening behavior, but this difference was not statistically significant (p = 0.33).
conclusionsA high percentage of both colorectal cancer cases and relatives sampled from the Seattle Colorectal Cancer Family Registry are interested in identifying their genetic status, discussing their genetic status with their family and doctor, and adopting behavioral changes that may reduce cancer risk.
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