ArticleInternational journal of cancer2008
Identification of the regions of the HPV 5 E6 protein involved in Bak degradation and inhibition of apoptosis.
Article in International journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Expression of 9-Life (Basel, Switzerland) · 2025Article
- Effects of β-HPV on DNA damage response pathways to drive carcinogenesis: a review.Virus genes · 2021Review
- Article
- Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology.Frontiers in oncology · 2019Review
- Epidemiology and biology of cutaneous human papillomavirus.Clinics (Sao Paulo, Brazil) · 2018Review
- HPV8-E6 Interferes with Syntenin-2 Expression through Deregulation of Differentiation, Methylation and Phosphatidylinositide-Kinase Dependent Mechanisms.Frontiers in microbiology · 2017Article
- Loss of Genome Fidelity: Beta HPVs and the DNA Damage Response.Frontiers in microbiology · 2017Review
- E6 proteins from low-risk human papillomavirus types 6 and 11 are able to protect keratinocytes from apoptosis via Bak degradation.The Journal of general virology · 2016Article
- Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis.Molecular cancer · 2015Article
- Papillomavirus E6 oncoproteins.Virology · 2013Review
- Allosteric conformational barcodes direct signaling in the cell.Structure (London, England : 1993) · 2013Review
- Case-control study of cutaneous human papillomaviruses in squamous cell carcinoma of the skin.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- The ubiquitin/proteasome system-dependent control of mitochondrial steps in apoptosis.Seminars in cell & developmental biology · 2012Review
- p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes.Journal of virology · 2012Article
- HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage.PLoS pathogens · 2012Article
- Papillomavirus E6 proteins.Virology · 2009Review
- Bax and Bak expression in cervical smears of women with low-and high-risk HPV types: A study of 120 cases.Journal of cytologyArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
UVB induced DNA damage is the major aetiological agent in NMSC development, but mounting evidence suggests a role for human papillomaviruses (HPV) from genus beta, including HPV 5 and HPV 8, in the development of NMSC on sun exposed body sites. We have previously shown that UVB activates Bak, an apoptogenic mitochondrial factor that, following an apoptotic stimulus, undergoes a conformational change that leads to pore formation in the mitochondrial membrane that releases apoptotic factors. The HPV E6 protein effectively inhibits UVB-induced apoptosis and targets Bak for proteolytic degradation. We have now identified the regions of the HPV5 E6 that are required to mediate Bak proteolysis and contribute toward the antiapoptotic activity of the protein. Interestingly, while wild-type HPV5 E6 does not bind or target p53 for proteolysis, we have isolated specific HPV5 E6 mutants that switch target specificity from Bak to p53 in a p53 codon 72 isoform-dependent manner. Furthermore, we demonstrate that the ability of wild-type HPV5 E6 to target Bak or specific E6 mutants to target p53 for proteolysis is not dependent on the E6-AP ubiquitin ligase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.