SynthesisAnnals of medicine2009
Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.
Synthesis in Annals of medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Association between interleukin-6 and preterm birth: a meta-analysis.Annals of medicine · 2023Pooled it
- Effect of interleukin-6 polymorphism on risk of preterm birth within population strata: a meta-analysis.BMC genetics · 2013Pooled it
- Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance.Metabolism: clinical and experimental · 2012Pooled it
- The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.Lancet (London, England) · 2012Pooled it
- The Single Nucleotide PolymorphismJournal of obesity · 2018Trial
- Association of the IL-6R rs2228145 polymorphism with diabetic nephropathy: A case-control study.Journal of diabetes investigation · 2025Article
- Innate-Immunity Genes in Obesity.Journal of personalized medicine · 2021Review
- Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus.World journal of hepatology · 2020Article
- Associations between metabolic syndrome components and markers of inflammation in Welsh school children.European journal of pediatrics · 2018Article
- Article
- Investigating the epigenetic profile of the inflammatory gene IL-6 in late-life depression.BMC psychiatry · 2017Article
- Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case-control study.BMC medical genetics · 2015Article
- TNF rs1799964 as a Predictive Factor of Acute Toxicities in Chinese Rectal Cancer Patients Treated With Chemoradiotherapy.Medicine · 2015Observational
- Genetic polymorphisms of cytokine genes in type 2 diabetes mellitus.World journal of diabetes · 2014Review
- Interleukin-6 gene polymorphisms, dietary fat intake, obesity and serum lipid concentrations in black and white South African women.Nutrients · 2014Article
- The relationship between dietary fatty acids and inflammatory genes on the obese phenotype and serum lipids.Nutrients · 2013Review
- Are centenarians genetically predisposed to lower disease risk?Age (Dordrecht, Netherlands) · 2012Article
- Common variants of IL6, LEPR, and PBEF1 are associated with obesity in Indian children.Diabetes · 2012Article
- The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy.PloS one · 2012Article
- Fatty acid-gene interactions, adipokines and obesity.European journal of clinical nutrition · 2011Review
Corrections and comments
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Authors and funding
36 authors at 16 institutions in 8 countries.
Funding
Abstract
backgroundSeveral studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results.
aimsThis joint analysis aimed to clarify whether IL6 -174G>C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI).
methodsIndividual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P>0.1), they were combined by using the inverse-variance fixed-effect model.
resultsThe main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174G>C and BMI or interleukin-6 levels, except in some subgroups.
conclusionsOur data suggest that C-allele carriers of the IL6 -174G>C polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.