Evidence map›Paper›PMID 18752000›Full record

ReviewPflugers Archiv : European journal of physiology2009

Micropuncturing the nephron.

Volker Vallon

Abstract readReview
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Characterization of renal NaCl and oxalate transport in Slc26a6American journal of physiology. Renal physiology · 2019
    Article
  11. Article
  12. Net KKidney international · 2017
    Article
  13. Article
  14. Deficient acid handling with distal RTA in the NBCe2 knockout mouse.American journal of physiology. Renal physiology · 2015
    Article
  15. Article
  16. Connecting tubule glomerular feedback in hypertension.Hypertension (Dallas, Tex. : 1979) · 2013
    Article
  17. Detection of endogenous substances with enzymatic microelectrode biosensors in the kidney.American journal of physiology. Regulatory, integrative and comparative physiology · 2013
    Review
  18. Proximal nephron.Comprehensive Physiology · 2013
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Volker VallonDepartment of Medicine, University of California San Diego & VA San Diego Healthcare System, 92161, USA. vvallon@ucsd.edu

Funding

GLOMERULAR AND TUBULAR FUNCTION IN THE DIABETIC KIDNEYR01DK056248 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI THOMSON, SCOTT CULVER · 1999 to 2014
$4.6M
AUTOREGULATION OF GLOMERULAR FILTRATION RATER01DK028602 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI BLANTZ, ROLAND C · 1986 to 2011
$3.9M
Adrenergic and Purinergic Regulation of Target CellsR01GM066232 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI INSEL, PAUL A · 2004 to 2010
$1.9M
Mechanism of Fetal and Neonatal Handling of HIV DrugsR01DK079784 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIGAM, SANJAY K · 2008 to 2011
$1.5M
Modulation of Diabetic Kidney Growth/HypertrophyR21DK070667 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI SATRIANO, JOSEPH · 2006 to 2007
$273k
NIDDK NIH HHS DK070667NIDDK NIH HHS DK079784NIDDK NIH HHS DK28602NIDDK NIH HHS DK56248NIDDK NIH HHS R01 DK028602NIDDK NIH HHS R01 DK056248NIDDK NIH HHS R01 DK079784NIDDK NIH HHS R21 DK070667NIGMS NIH HHS GM66232NIGMS NIH HHS R01 GM066232
6 · The paper itself

Abstract

To achieve the role of the kidney in maintaining body homeostasis, the renal vasculature, the glomeruli, and the various segments of the nephron and the collecting duct system have to fulfill very diverse and specific functions. These functions are dependent on a complex renal architecture and are regulated by systemic hemodynamics, hormones, and nerves. As a consequence, to better understand the physiology of the kidney, methods are necessary that allow insights on the function of these diverse structures in the physiological context of the intact kidney. The renal micropuncture technique allows direct access to study superficial nephrons in vivo. In this review, the application of micropuncture techniques on the single nephron level is outlined as an approach to better understand aspects of glomerular filtration, tubular transport, and tubulo-glomerular communication. Studies from the author's lab, including experiments in gene-targeted mice, are briefly presented to illustrate some of the approaches and show how they can further advance our understanding of the molecular mechanisms involved in the regulation of kidney function.

Indexed as

PuncturesAnimalsCalcium ChannelsGlucoseHemodynamicsKidney GlomerulusMiceNephronsPotassiumRatsTRPV Cation ChannelsCalcium ChannelsGlucosePotassiumTrpv5 protein, mouseTRPV Cation Channels

Identifiers

PMID18752000
PMCPMC2954491

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.