ArticleHSS journal : the musculoskeletal journal of Hospital for Special Surgery2006
How much calcium is in your drinking water? A survey of calcium concentrations in bottled and tap water and their significance for medical treatment and drug administration.
Article in HSS journal : the musculoskeletal journal of Hospital for Special Surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- The dietary management of calcium and phosphate in children with CKD stages 2-5 and on dialysis-clinical practice recommendation from the Pediatric Renal Nutrition Taskforce.Pediatric nephrology (Berlin, Germany) · 2020Guideline
- Distribution and seasonality of potentially toxic elements (PTEs) in the waters of the Negro river in Manaus, Amazonas, Brazil.Scientific reports · 2026Article
- Groundwater Hardness and Alkalinity As Risk Factors for Kidney Stone Disease in Alwar, India: An Ecological Study.Cureus · 2024Article
- Article
- Feasibility of increasing calcium content of drinking tap water following quality regulations to improve calcium intake at population level.Gates open research · 2024Article
- Article
- Effect of Drinking Water Salt Content on the Interaction between Surfactants and Bacteria.Microbiology spectrum · 2023Article
- Soaking beans for 12 h reduces split percent and cooking time regardless of type of water used for cooking.Heliyon · 2022Article
- Does It Bind? A Method to Determine the Affinity of Calcium and Magnesium Ions for Polymers UsingAnalytical chemistry · 2022Article
- Fracture rates and economic outcomes in patients with osteoporosis prescribed risedronate gastro-resistant versus other oral bisphosphonates: a claims data analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Optimal Dosing Regimen of Osteoporosis Drugs in Relation to Food Intake as the Key for the Enhancement of the Treatment Effectiveness-A Concise Literature Review.Foods (Basel, Switzerland) · 2021Review
- Testing for sensory threshold in drinking water with added calcium: a first step towards developing a calcium fortified water.Gates open research · 2021Article
- Current calcium fortification experiences: a review.Annals of the New York Academy of Sciences · 2021Review
- Contribution of calcium in drinking water from a South American country to dietary calcium intake.BMC research notes · 2020Article
- Quantification of Elemental Contaminants in Unregulated Water across Western Navajo Nation.International journal of environmental research and public health · 2019Article
- Metabolic Syndrome Features: Is There a Modulation Role by Mineral Water Consumption? A Review.Nutrients · 2019Review
- Nanoparticle- and microparticle-based luminescence imaging of chemical species and temperature in aquatic systems: a review.Mikrochimica acta · 2019Article
- Life-course approach to nutrition.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Review
- Towards the Physics of Calcium Signalling in Plants.Plants (Basel, Switzerland) · 2013Review
- Zoledronic acid infusion for prevention and treatment of osteoporosis.International journal of women's health · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDifferent forms of water vary in calcium content. High divalent ion (i.e., Ca(2+), Mg(2+), etc.) concentration is deleterious to the absorption and efficacy of the bisphosphonate group of drugs in osteoporosis treatment. Water with high calcium concentration may also present an alternate pathway of calcium administration. In either case, knowing the actual concentration is critical. HYPOTHESIS: The current paper is a surveillance study. We hypothesize that there is considerable variation in the calcium concentrations in the various water sources: tap water from US and Canadian cities of different regions and purified, spring, and mineral bottled waters. In addition, we hypothesize that the water filter removes a significant amount of minerals including calcium from the water. METHODOLOGY: Calcium concentrations in various city tap waters, as well as an assorted number of bottled waters, were determined through the direct inspection of scientific data. The effect of filtering was also determined by mineral analysis of mineral water directly before and after filtration.
resultThe calcium concentration of water varies from 1 to 135 mg/L across the USA and Canada. Most spring waters were found to have a relatively low calcium concentration, with an average of 21.8 mg/L. Purified waters contain a negligible calcium concentration. Mineral waters, on the other hand, were generally found to contain higher calcium concentrations, an average of 208 mg/L of calcium. Filtration was found to remove a considerable amount of calcium from the water, removing 89% on average.
conclusionCalcium concentration in water varied substantially from different sources in the USA and Canada. Bottled waters presented with concentrations of calcium covering a very large range. Certain tap and bottled waters present with concentrations of calcium sufficient to exhibit a deleterious effect on bisphosphonate treatment. Alternatively, certain waters may be used as a source of calcium that may provide over 40% of the recommended daily intake for calcium.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.