ArticleHistochemistry and cell biology2009
The spatial and temporal expression of delta-like protein 1 in the rat pituitary gland during development.
Article in Histochemistry and cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Pathogenesis, clinical features, and treatment of plurihormonal pituitary adenoma.Frontiers in neuroscience · 2023Review
- Gonadotroph tumours with a low SF-1 labelling index are more likely to recur and are associated with enrichment of the PI3K-AKT pathway.Neuropathology and applied neurobiology · 2021Article
- Similarities and differences in tissue distribution of DLK1 and DLK2 during E16.5 mouse embryogenesis.Histochemistry and cell biology · 2019Article
- Expression and localization of forkhead box protein FOXJ1 in S100β-positive multiciliated cells of the rat pituitary.Medical molecular morphology · 2017Article
- Easy detection of hormone secretion from LβT2 cells by using Gaussia luciferase.The Journal of reproduction and development · 2017Article
- Intracellular localization of α-tubulin acetyltransferase ATAT1 in rat ciliated cells.Medical molecular morphology · 2016Article
- Morphological, biochemical, transcriptional and epigenetic responses to fasting and refeeding in intestine of Xenopus laevis.Cell & bioscience · 2016Article
- The elongation of primary cilia via the acetylation of α-tubulin by the treatment with lithium chloride in human fibroblast KD cells.Medical molecular morphology · 2015Article
- Pituitary phenotypes of mice lacking the notch signalling ligand delta-like 1 homologue.Journal of neuroendocrinology · 2013Article
- Analysis of differential gene expression in plurihormonal pituitary adenomas using bead-based fiber-optic arrays.Journal of neuro-oncology · 2012Article
- Expression of IGFBP7 mRNA in corticotrophs in the anterior pituitary of adrenalectomized rats.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Extending the knowledge in histochemistry and cell biology.Histochemistry and cell biology · 2010Review
- Article
- State-of-the-art technologies, current opinions and developments, and novel findings: news from the field of histochemistry and cell biology.Histochemistry and cell biology · 2008Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An analysis of secreted proteins by the signal sequence trap method using a cDNA library of the rat pituitary anlage at embryonic days (E) 13.5 revealed the abundant expression of delta-like protein 1 (Dlk1) in the pituitary gland. Dlk1, an epidermal growth factor-like repeat protein in preadipocytes, functions in maintaining the preadipose state. Expression of Dlk1 mRNA in the pituitary at E13.5 and in the adult pituitary was confirmed by in situ hybridization. The expression pattern of Dlk1 during pituitary development was also studied by immunohistochemistry. Dlk1 protein first appeared in Rathke's pouch and the infundibulum at E11.5; as development proceeded, expression became restricted to the pars distalis and pars tuberalis (PT). Dlk1 was expressed in most ACTH cells during the embryonic stages, but its expression was limited to only a few ACTH cells in the adult pituitary. It was also expressed in a small population of TSH, GTH, and PRL cells throughout development, whereas it was present in the cytoplasm of most GH cells at all developmental stages. Similarly, Dlk1 was localized in the cytoplasm of PT cells during development. These findings provide new insights into the mechanism of Dlk1 regarding its regulation of pituitary hormone-secreting cells during development.
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