Trial reportInternational orthopaedics2009
Correlation between synovial fluid and serum IL-1beta levels after ACL surgery-preliminary report.
Trial report in International orthopaedics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Arthroscopic primary repair of the anterior cruciate ligament with internal brace ligament augmentation: a viable alternative to reconstruction? A systematic literature review and analysis.BMC musculoskeletal disorders · 2026Pooled it
- Polymorphism of Genes Encoding Inflammatory Interleukins and the Risk of Anterior Cruciate Ligament Injury: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2024Pooled it
- Intraarticular application of autologous conditioned serum (ACS) reduces bone tunnel widening after ACL reconstructive surgery in a randomized controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2011Trial
- Synovial Fluid Biomarkers Associated With Anterior Cruciate Ligament Injury and Reconstruction: A Systematic Review.Orthopaedic journal of sports medicine · 2026Review
- Synovial Fluid and Serum Inflammation Biomarkers After Autologous Matrix-Induced Chondrogenesis (AMIC) for Knee Chondral Defects.Journal of clinical medicine · 2026Article
- Anterior Screw Insertion Results in Greater Tibial Tunnel Enlargement Rates after Single-Bundle Anterior Cruciate Ligament Reconstruction than Posterior Insertion: A Retrospective Study.Medicina (Kaunas, Lithuania) · 2023Article
- A2M inhibits inflammatory mediators of chondrocytes by blocking IL-1β/NF-κB pathway.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Article
- Dynamic intraligamentary stabilization: novel technique for preserving the ruptured ACL.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Article
- Dynamic Intraligamentary Stabilization (DIS) for treatment of acute anterior cruciate ligament ruptures: case series experience of the first three years.BMC musculoskeletal disorders · 2015Article
- Mechanisms of post-traumatic osteoarthritis after ACL injury.Current rheumatology reports · 2014Review
- Identification of α2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- Anterior cruciate ligament regeneration using mesenchymal stem cells and collagen type I scaffold in a rabbit model.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Article
- Use of autologous conditioned serum (Orthokine) for the treatment of the degenerative osteoarthritis of the temporomandibular joint. Review of the literature.Medicina oral, patologia oral y cirugia bucal · 2013Review
- Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway.Arthritis research & therapy · 2012Article
- Response of human engineered cartilage based on articular or nasal chondrocytes to interleukin-1β and low oxygen.Tissue engineering. Part A · 2012Article
- Engineered cartilage maturation regulates cytokine production and interleukin-1β response.Clinical orthopaedics and related research · 2011Article
- Response to: cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection.Arthritis research & therapy · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The possibility of controlling the harmful intra-articular influence of elevated interleukin (IL)-1beta synovial fluid concentration after anterior cruciate ligament (ACL) surgery could be useful. We investigated the correlation between serum and synovial fluid IL-1beta levels following ACL reconstruction. We measured IL-1beta concentration periodically in three synovial fluid and four serum samples in each of 20 patients receiving either autologous conditioned serum (ACS) containing endogenous anti-inflammatory cytokines including IL-1Ra and several growth factors (group A) or placebo (group B). A decrease in IL-1beta synovial fluid concentration appeared to be more pronounced in absolute terms in group A. In eight patients serum IL-1beta was detected on the 6th postoperative day. In four of them whose synovial fluid levels were over 10 pg/ml on the 6th postoperative day, serum IL-1beta was detected on the 10th postoperative day. The results were different in group B. Correlation between serum and synovial fluid IL-1beta appearance persists in patients after ACL surgery and ACS application. This study is an example of ACS influence on the ACL healing process controlling the IL-1beta levels on the basis of the serum IL-1beta detection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.