ArticleThe Journal of cell biology1991
EA-1, a novel adhesion molecule involved in the homing of progenitor T lymphocytes to the thymus.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 53 citations in OpenAlex.
- PECAM-1/CD31 trans-homophilic binding at the intercellular junctions is independent of its cytoplasmic domain; evidence for heterophilic interaction with integrin alphavbeta3 in Cis.Molecular biology of the cell · 2000Article
- Alpha 6 integrins are required for Langerhans cell migration from the epidermis.The Journal of experimental medicine · 1997Article
- Predominant role of alpha 4-integrins for distinct steps of lymphoma metastasis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The L1 adhesion molecule is a cellular ligand for VLA-5.The Journal of cell biology · 1995Article
- In vivo sequestration of Plasmodium falciparum-infected human erythrocytes: a severe combined immunodeficiency mouse model for cerebral malaria.The Journal of experimental medicine · 1995Article
- Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand.The Journal of experimental medicine · 1995Article
- Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells.The Journal of experimental medicine · 1995Article
- Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse.The American journal of pathology · 1994Article
- Alpha 6 integrin distribution in human embryonic and adult tissues.Histochemistry · 1994Article
- A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Polarity and reorganization of the endoplasmic reticulum during fertilization and ooplasmic segregation in the ascidian egg.The Journal of cell biology · 1993Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse progenitor T lymphocyte (pro-T) cell line FTF1 binds in vitro to thymus blood vessels, the thymic capsule, and liver from newborn mice. A mAb, EA-1, raised against an embryonic mouse endothelial cell line, blocked adhesion. The antibody also interfered with pro-T cell adhesion to a thymus-derived mouse endothelial cell line; it had no effect on the adhesion of mature T lymphocytes and myeloid cells. The antigen recognized by EA-1 is located on the vascular endothelium of various mouse tissues and absent on pro-T cells. EA-1 antibody precipitates molecules with apparent molecular weights of 110,000, 140,000, 160,000, and 200,000. Immunoclearing and binding-inhibition studies with antibodies against known adhesion molecules suggest that the EA-1 antigen is a novel adhesion molecule involved in colonization of the embryonic thymus by T cell progenitors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.