Trial reportThe Journal of infectious diseases2008
Repeated treatments with albendazole enhance Th2 responses to Ascaris Lumbricoides, but not to aeroallergens, in children from rural communities in the Tropics.
Trial report in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Impact of Anthelmintic Therapy for Invasive Helminth Infection on Microbial Translocation, Inflammation, and Immune Response among Ugandans Living with HIV: A Randomized Proof of Concept Study.The American journal of tropical medicine and hygiene · 2025Trial
- Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum.Malaria journal · 2013Trial
- Changes in plasma cytokines after treatment of ascaris lumbricoides infection in individuals with HIV-1 infection.The Journal of infectious diseases · 2010Trial
- Larval Ascariasis Triggers Unresolved Anemia, Persistent Inflammation, and Chronic Pulmonary Disease after Single and Reinfection in a Dose-Dependent Manner in Mice.ACS infectious diseases · 2025Article
- Effect of linex treatment on IFN-γ and IL-4 in mice infected with Trichinella.BMC infectious diseases · 2024Article
- Therapeutic effects of myrrh extract and myrrh-based silver nanoparticles onFrontiers in veterinary science · 2024Article
- Whipworm and roundworm infections.Nature reviews. Disease primers · 2020Review
- Soil-transmitted helminth parasites and allergy: Observations from Ecuador.Parasite immunology · 2019Review
- Influence of Parasitic Worm Infections on Allergy Diagnosis in Sub-Saharan Africa.Current allergy and asthma reports · 2017Review
- Community deworming alleviates geohelminth-induced immune hyporesponsiveness.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Interleukin-10 and soil-transmitted helminth infections in Honduran children.BMC research notes · 2015Article
- Effective anthelmintic therapy of residents living in endemic area of high prevalence for Hookworm and Schistosoma mansoni infections enhances the levels of allergy risk factor anti-Der p1 IgE.Results in immunology · 2015Article
- A bipolar disorder patient becoming asymptomatic after adjunctive anti-filiarasis treatment: a case report.BMC psychiatry · 2013Article
- New Allergens of Relevance in Tropical Regions: The Impact of Ascaris lumbricoides Infections.The World Allergy Organization journal · 2011Article
- Pulmonary ascariasis: two cases in Austria and review of the literature.Wiener klinische Wochenschrift · 2010Review
- Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network.Infection and immunity · 2010Article
- Interactions between helminth parasites and allergy.Current opinion in allergy and clinical immunology · 2009Review
- M-RNA Gene Expression of INF-Γ and IL-10 during Intestinal Phase ofIranian journal of parasitologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
Geohelminth infections are associated with modulation of immunity to parasite antigens and aeroallergens. To investigate the possibility that this modulation is affected by anthelmintic treatment, we compared cytokine responses in children who were treated with repeated doses of albendazole over 1 year versus those in children who had were not treated. Whole-blood samples were cultured with Ascaris antigen and house dust mite and cockroach allergens, and levels of interleukin (IL)-5, IL-13, interferon-gamma, and IL-10 were measured. Anthelmintic treatment was associated with enhanced production of Th2 cytokines in response to parasite antigen but did not affect responses to aeroallergens. The data indicate that long-term treatment may be associated with increased Th2 antiparasite immunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.